Isolation and Asymmetric Total Synthesis of Perforanoid A
Lv, Chao; Yan, Xiaohui; Tu, Qian; Di, Yingtong; Yuan, Chunmao; Fang, Xin; Ben-David, Yaacove; Xia, Lei; Gong, Jianxian; Shen, Yuemao; Yang, Zhen; Hao, Xiaojiang
2016-06-20
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号55期号:26页码:7539-7543
摘要A novel limonoid, perforanoid A, was isolated, and an asymmetric total synthesis was achieved in 10 steps. The key steps are chiral tertiary aminonaphthol mediated enantioselective alkenylation of an aldehyde to an allylic alcohol, Pd-catalyzed coupling of the allylic alcohol with vinyl ether to form the gamma-lactone ring, and cyclopentenone ring formation through a Rh-catalyzed Pauson-Khand reaction. Preliminary studies show that perforanoid A is cytotoxic towards HEL, K562, and CB3 tumor cell lines.
关键词Asymmetric Synthesis Cytotoxicity Limonoids Pauson-khand Reaction Total Synthesis
DOI10.1002/anie.201602783
收录类别SCI
语种英语
WOS记录号WOS:000383077400042
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/28626
专题植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Lv, Chao,Yan, Xiaohui,Tu, Qian,et al. Isolation and Asymmetric Total Synthesis of Perforanoid A[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(26):7539-7543.
APA Lv, Chao.,Yan, Xiaohui.,Tu, Qian.,Di, Yingtong.,Yuan, Chunmao.,...&Hao, Xiaojiang.(2016).Isolation and Asymmetric Total Synthesis of Perforanoid A.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(26),7539-7543.
MLA Lv, Chao,et al."Isolation and Asymmetric Total Synthesis of Perforanoid A".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.26(2016):7539-7543.
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