Bioactive sesquiterpenoids from the flowers of Inula japonica
Wu, Xing-De; Ding, Lin-Fen; Tu, Wen-Chao; Yang, Hui; Su, Jia; Peng, Li-Yan; Li, Yan; Zhao, Qin-Shi
2016-09-01
发表期刊PHYTOCHEMISTRY
卷号129页码:68-76
摘要Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-K alpha Xray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL 60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 mu M. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Inula Japonica Asteraceae Sesquiterpenoids Inujaponins A-i Cytotoxicity Nitric Oxide (No)
DOI10.1016/j.phytochem.2016.07.008
收录类别SCI
语种英语
WOS记录号WOS:000381832900007
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/28575
专题植物化学与西部植物资源持续利用国家重点实验室
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Wu, Xing-De,Ding, Lin-Fen,Tu, Wen-Chao,et al. Bioactive sesquiterpenoids from the flowers of Inula japonica[J]. PHYTOCHEMISTRY,2016,129:68-76.
APA Wu, Xing-De.,Ding, Lin-Fen.,Tu, Wen-Chao.,Yang, Hui.,Su, Jia.,...&Zhao, Qin-Shi.(2016).Bioactive sesquiterpenoids from the flowers of Inula japonica.PHYTOCHEMISTRY,129,68-76.
MLA Wu, Xing-De,et al."Bioactive sesquiterpenoids from the flowers of Inula japonica".PHYTOCHEMISTRY 129(2016):68-76.
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