Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives
Yu, Qun-Ying1,2; Zhong, Hong-Ming1,2; Sun, Wen-Wu1,2; Zhang, Shi-Jin1,4; Cao, Pei1; Dong, Xiao-Ping4; Qin, Hong-Bo1; Liu, Ji-Kai3; Wu, Bin1,3
2016-05-01
Source PublicationASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume5Issue:5Pages:608-612
AbstractThe study of Pd-catalyzed arylation, alkoxylation, and acyloxylation reactions at the C3 position of L-pipecolinic acid derivatives to afford cis-disubstituted piperidines as single stereoisomers was performed. To demonstrate the utility of the reaction, compound 10, an analogue of (-)-3S-3-PPP (9) that is used as a neuroleptic drug for the treatment of schizophrenia, was synthesized featuring the arylation and radical decarboxylation reactions as key steps.
KeywordAlkoxylation Arylation C-h Activation Palladium Pipecolinic Acid
DOI10.1002/ajoc.201600072
Indexed BySCI
Language英语
WOS IDWOS:000380259700002
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/28511
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
4.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China
Recommended Citation
GB/T 7714
Yu, Qun-Ying,Zhong, Hong-Ming,Sun, Wen-Wu,et al. Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2016,5(5):608-612.
APA Yu, Qun-Ying.,Zhong, Hong-Ming.,Sun, Wen-Wu.,Zhang, Shi-Jin.,Cao, Pei.,...&Wu, Bin.(2016).Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives.ASIAN JOURNAL OF ORGANIC CHEMISTRY,5(5),608-612.
MLA Yu, Qun-Ying,et al."Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives".ASIAN JOURNAL OF ORGANIC CHEMISTRY 5.5(2016):608-612.
Files in This Item: Download All
File Name/Size DocType Version Access License
yu2016.pdf(883KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu, Qun-Ying]'s Articles
[Zhong, Hong-Ming]'s Articles
[Sun, Wen-Wu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu, Qun-Ying]'s Articles
[Zhong, Hong-Ming]'s Articles
[Sun, Wen-Wu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu, Qun-Ying]'s Articles
[Zhong, Hong-Ming]'s Articles
[Sun, Wen-Wu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: yu2016.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.