| Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives | |
Yu, Qun-Ying1,2; Zhong, Hong-Ming1,2; Sun, Wen-Wu1,2 ; Zhang, Shi-Jin1,4; Cao, Pei1; Dong, Xiao-Ping4; Qin, Hong-Bo1; Liu, Ji-Kai3; Wu, Bin1,3
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| 2016-05-01 | |
| 发表期刊 | ASIAN JOURNAL OF ORGANIC CHEMISTRY
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| 卷号 | 5期号:5页码:608-612 |
| 摘要 | The study of Pd-catalyzed arylation, alkoxylation, and acyloxylation reactions at the C3 position of L-pipecolinic acid derivatives to afford cis-disubstituted piperidines as single stereoisomers was performed. To demonstrate the utility of the reaction, compound 10, an analogue of (-)-3S-3-PPP (9) that is used as a neuroleptic drug for the treatment of schizophrenia, was synthesized featuring the arylation and radical decarboxylation reactions as key steps. |
| 关键词 | Alkoxylation Arylation C-h Activation Palladium Pipecolinic Acid |
| DOI | 10.1002/ajoc.201600072 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380259700002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/28511 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 611137, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Qun-Ying,Zhong, Hong-Ming,Sun, Wen-Wu,et al. Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2016,5(5):608-612. |
| APA | Yu, Qun-Ying.,Zhong, Hong-Ming.,Sun, Wen-Wu.,Zhang, Shi-Jin.,Cao, Pei.,...&Wu, Bin.(2016).Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives.ASIAN JOURNAL OF ORGANIC CHEMISTRY,5(5),608-612. |
| MLA | Yu, Qun-Ying,et al."Palladium-Catalyzed C(sp(3))-H Functionalization at the C3 Position of L-Pipecolinic Acid Derivatives".ASIAN JOURNAL OF ORGANIC CHEMISTRY 5.5(2016):608-612. |
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| yu2016.pdf（883KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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