Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens
He, Kang; Geng, Chang-An; Cao, Tuan-Wu; Wang, Hong-Ling; Ma, Yun-Bao; Zhang, Xue-Mei; Chen, Ji-Jun
2016
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume18Issue:6Pages:528-534
AbstractTwo new secoiridoids, swerpatic acid (1) with an unusual C-8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.
KeywordSwertia Patens Secoiridoids Swerpatic Acid Swerpalactone Anti-hbv Activity
DOI10.1080/10286020.2015.1116523
Indexed BySCI
Language英语
WOS IDWOS:000379666400003
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/28476
Collection植物化学与西部植物资源持续利用国家重点实验室
AffiliationChinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
He, Kang,Geng, Chang-An,Cao, Tuan-Wu,et al. Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(6):528-534.
APA He, Kang.,Geng, Chang-An.,Cao, Tuan-Wu.,Wang, Hong-Ling.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2016).Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(6),528-534.
MLA He, Kang,et al."Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.6(2016):528-534.
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