Chemical constituents from Piper hainanense and their cytotoxicities
Shi, Yan-Ni1,2; Xin, Ying1,2; Ling, Yi1,2; Li, Xing-Cong3; Hao, Chao-Yun4; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
2016
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume18Issue:8Pages:730-736
AbstractTwo new compounds, (Z,R)-1-phenylethylcinnamate (1) and (1R,2R,3R,6S)-pipoxide (2) were isolated from the aerial part of Piper hainanense, along with 12 known compounds, including nine benzene derivatives (4-11), one isobutylamide (12), and two polyoxygenated cyclohexene derivatives (13-14). Their structures were elucidated on the basis of the HRESIMS, 1D and 2D NMR spectroscopic analyses, and ECD in cases of 2 and 3. The absolute configuration of ellipeiopsol B (3) was determined for the first time. All these compounds 1-14 were reported from the titled plant for the first time. Most of the isolates were tested for their cytotoxicities against five human cancer cell lines. Four of which, 2, 3, 9, 14 showed moderate bioactivities. Among them, the new compound 2 showed potential cytotoxicity against SMMC-7721, MCF-7, and SW-480 with IC50 values of 9.7, 15.0, and 13.2M, respectively.
KeywordPiperaceae Piper Hainanense Cytotoxicity Polyoxygenated Cyclohexene Derivatives Benzene Derivatives Pipoxide
DOI10.1080/10286020.2016.1158709
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000379739300003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/28471
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
4.Chinese Acad Trop Agr Sci, Inst Spice & Beverage Res, Hainan 100049, Peoples R China
Recommended Citation
GB/T 7714
Shi, Yan-Ni,Xin, Ying,Ling, Yi,et al. Chemical constituents from Piper hainanense and their cytotoxicities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(8):730-736.
APA Shi, Yan-Ni.,Xin, Ying.,Ling, Yi.,Li, Xing-Cong.,Hao, Chao-Yun.,...&Zhang, Ying-Jun.(2016).Chemical constituents from Piper hainanense and their cytotoxicities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(8),730-736.
MLA Shi, Yan-Ni,et al."Chemical constituents from Piper hainanense and their cytotoxicities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.8(2016):730-736.
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