| Chemical constituents from Piper hainanense and their cytotoxicities | |
Shi, Yan-Ni1,2; Xin, Ying1,2; Ling, Yi1,2; Li, Xing-Cong3; Hao, Chao-Yun4; Zhu, Hong-Tao1; Wang, Dong1 ; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1
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| 2016 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 卷号 | 18期号:8页码:730-736 |
| 摘要 | Two new compounds, (Z,R)-1-phenylethylcinnamate (1) and (1R,2R,3R,6S)-pipoxide (2) were isolated from the aerial part of Piper hainanense, along with 12 known compounds, including nine benzene derivatives (4-11), one isobutylamide (12), and two polyoxygenated cyclohexene derivatives (13-14). Their structures were elucidated on the basis of the HRESIMS, 1D and 2D NMR spectroscopic analyses, and ECD in cases of 2 and 3. The absolute configuration of ellipeiopsol B (3) was determined for the first time. All these compounds 1-14 were reported from the titled plant for the first time. Most of the isolates were tested for their cytotoxicities against five human cancer cell lines. Four of which, 2, 3, 9, 14 showed moderate bioactivities. Among them, the new compound 2 showed potential cytotoxicity against SMMC-7721, MCF-7, and SW-480 with IC50 values of 9.7, 15.0, and 13.2M, respectively. |
| 关键词 | Piperaceae Piper Hainanense Cytotoxicity Polyoxygenated Cyclohexene Derivatives Benzene Derivatives Pipoxide |
| DOI | 10.1080/10286020.2016.1158709 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379739300003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/28471 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA 4.Chinese Acad Trop Agr Sci, Inst Spice & Beverage Res, Hainan 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Yan-Ni,Xin, Ying,Ling, Yi,et al. Chemical constituents from Piper hainanense and their cytotoxicities[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2016,18(8):730-736. |
| APA | Shi, Yan-Ni.,Xin, Ying.,Ling, Yi.,Li, Xing-Cong.,Hao, Chao-Yun.,...&Zhang, Ying-Jun.(2016).Chemical constituents from Piper hainanense and their cytotoxicities.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,18(8),730-736. |
| MLA | Shi, Yan-Ni,et al."Chemical constituents from Piper hainanense and their cytotoxicities".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 18.8(2016):730-736. |
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| 10.1080@10286020.201（893KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
| 10.1080@10286020.201（893KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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