Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models

doi:10.1002/ptr.1918

	Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models
	Wu, Yihang ; Zhou, Changxin ; Li, Xiangping ; Song, Liyan ; Wu, Xiumei ; Lin, Wenyan ; Chen, Haiyong ; Bai, Hua ; Zhao, Jun ; Zhang, Rongping ; Sun, Handong; Zhao, Yu
通讯作者	dryuzhao@zju.edu.cn
	2006-07-01
发表期刊	PHYTOTHERAPY RESEARCH
ISSN	0951-418X
卷号	20 期号:7 页码:585-590
摘要	The antiinflammatory effect of the total flavonoids of Laggera pterodonta (TFLP) was evaluated with various in vivo models of both acute and chronic inflammation. In the acute inflammation tests, TFLP significantly inhibited xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. In the carrageenan-induced rat pleurisy model, TFLP efficiently suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the activity of serum superoxide dismutase (SOD), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in the pleural exudates. No marked effect of TFLP on the activity of serum glutathione peroxidase (GSH-PX) was observed. In the chronic inflammation experiment, TFLP inhibited cotton pellet-induced rat granuloma. The antiinflammatory mechanisms of TFLP are probably associated with the inhibition of prostaglandin formation, influence on the antioxidant systems and the suppression of LZM release. The acute toxicity study revealed that TFLP was nontoxic in mice up to an oral dose of 7.5 g/kg body weight. Copyright (c) 2006 John Wiley & Sons, Ltd.
关键词	Laggera Pterodonta Phytomedicine Antiinflammation Total Flavonoids
学科领域	Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1002/ptr.1918
收录类别	SCI
语种	英语
WOS记录号	WOS:000239216900012
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2841
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Zhejiang Univ, Dept Tradit Chinese Med & Nat Drug Res, Coll Pharmaceut Sci, Hangzhou 310031, Peoples R China 2.Zhejang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China 3.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yihang,Zhou, Changxin,Li, Xiangping,et al. Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models[J]. PHYTOTHERAPY RESEARCH,2006,20(7):585-590.
APA	Wu, Yihang.,Zhou, Changxin.,Li, Xiangping.,Song, Liyan.,Wu, Xiumei.,...&Zhao, Yu.(2006).Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models.PHYTOTHERAPY RESEARCH,20(7),585-590.
MLA	Wu, Yihang,et al."Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models".PHYTOTHERAPY RESEARCH 20.7(2006):585-590.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
201111220017.pdf（173KB）			开放获取	--	浏览下载