Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models
Wu, Yihang; Zhou, Changxin; Li, Xiangping; Song, Liyan; Wu, Xiumei; Lin, Wenyan; Chen, Haiyong; Bai, Hua; Zhao, Jun; Zhang, Rongping; Sun, Handong; Zhao, Yu
2006-07-01
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号20期号:7页码:585-590
摘要The antiinflammatory effect of the total flavonoids of Laggera pterodonta (TFLP) was evaluated with various in vivo models of both acute and chronic inflammation. In the acute inflammation tests, TFLP significantly inhibited xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. In the carrageenan-induced rat pleurisy model, TFLP efficiently suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the activity of serum superoxide dismutase (SOD), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in the pleural exudates. No marked effect of TFLP on the activity of serum glutathione peroxidase (GSH-PX) was observed. In the chronic inflammation experiment, TFLP inhibited cotton pellet-induced rat granuloma. The antiinflammatory mechanisms of TFLP are probably associated with the inhibition of prostaglandin formation, influence on the antioxidant systems and the suppression of LZM release. The acute toxicity study revealed that TFLP was nontoxic in mice up to an oral dose of 7.5 g/kg body weight. Copyright (c) 2006 John Wiley & Sons, Ltd.
关键词Laggera Pterodonta Phytomedicine Antiinflammation Total Flavonoids
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.1918
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000239216900012
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2841
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Zhejiang Univ, Dept Tradit Chinese Med & Nat Drug Res, Coll Pharmaceut Sci, Hangzhou 310031, Peoples R China
2.Zhejang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China
3.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China
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Wu, Yihang,Zhou, Changxin,Li, Xiangping,et al. Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models[J]. PHYTOTHERAPY RESEARCH,2006,20(7):585-590.
APA Wu, Yihang.,Zhou, Changxin.,Li, Xiangping.,Song, Liyan.,Wu, Xiumei.,...&Zhao, Yu.(2006).Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models.PHYTOTHERAPY RESEARCH,20(7),585-590.
MLA Wu, Yihang,et al."Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models".PHYTOTHERAPY RESEARCH 20.7(2006):585-590.
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