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题名: Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models
作者: Wu, Yihang; Zhou, Changxin; Li, Xiangping; Song, Liyan; Wu, Xiumei; Lin, Wenyan; Chen, Haiyong; Bai, Hua; Zhao, Jun; Zhang, Rongping; null(孙汉董); Zhao, Yu
刊名: PHYTOTHERAPY RESEARCH
关键词: Laggera pterodonta ; phytomedicine ; antiinflammation ; total flavonoids
英文摘要: The antiinflammatory effect of the total flavonoids of Laggera pterodonta (TFLP) was evaluated with various in vivo models of both acute and chronic inflammation. In the acute inflammation tests, TFLP significantly inhibited xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. In the carrageenan-induced rat pleurisy model, TFLP efficiently suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the activity of serum superoxide dismutase (SOD), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in the pleural exudates. No marked effect of TFLP on the activity of serum glutathione peroxidase (GSH-PX) was observed. In the chronic inflammation experiment, TFLP inhibited cotton pellet-induced rat granuloma. The antiinflammatory mechanisms of TFLP are probably associated with the inhibition of prostaglandin formation, influence on the antioxidant systems and the suppression of LZM release. The acute toxicity study revealed that TFLP was nontoxic in mice up to an oral dose of 7.5 g/kg body weight. Copyright (c) 2006 John Wiley & Sons, Ltd.
出版日期: 2006-07-01
卷号: 20, 期号:7, 页码:585-590
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0951-418X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2841
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Zhejiang Univ, Dept Tradit Chinese Med & Nat Drug Res, Coll Pharmaceut Sci, Hangzhou 310031, Peoples R China
2.Zhejang Hisun Nat Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China
3.Kunming Med Coll, Dept Pharmacol, Kunming 650031, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China

Recommended Citation:
Wu, YH; Zhou, CX; Li, XP; Song, LY; Wu, XM; Lin, WY; Chen, HY; Bai, H; Zhao, J; Zhang, RP; Sun, HD; Zhao, Y.Evaluation of antiinflammatory activity of the total flavonoids of Laggera pterodonta on acute and chronic inflammation models,PHYTOTHERAPY RESEARCH,2006,20(7):585-590
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