KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway
Kong, Yanjie1,2; Li, Fubin1,2; Nian, Yin1,3; Zhou, Zhongmei1; Yang, Runxiang4; Qiu, Ming-Hua3; Chen, Ceshi1
2016
Source PublicationTHERANOSTICS
Volume6Issue:6Pages:875-886
AbstractTriterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis. In this study, KHF16 (24-acetylisodahurinol-3-O-beta-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ER alpha/PR/HER2 triple-negative breast cancer (TNBC) cell lines. KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines. KHF16 reduces the expression levels of XIAP, Mcl-1, Survivin and Cyclin B1/D1 proteins. Importantly, KHF16 inhibits TNF alpha-induced IKK alpha/beta phosphorylation, IKB alpha phosphorylation, p65 nuclear translocation and NF-kappa B downstream target gene expression, including XIAP, Mcl-1 and Survivin, in TNBC cells. These results suggest that KHF16 may inhibit TNBC by blocking the NF-kappa B signaling pathway in part.
KeywordKhf16 Cycloartane Triterpenoid Triple Negative Breast Cancer Cell Cycle Apoptosis Nf-kappa b
DOI10.7150/thno.14694
Indexed BySCI
Language英语
WOS IDWOS:000377798800010
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26280
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
4.Kunming Med Univ, Affiliated Hosp 3, Dept Med Oncol 2, Kunming 650118, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Kong, Yanjie,Li, Fubin,Nian, Yin,et al. KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway[J]. THERANOSTICS,2016,6(6):875-886.
APA Kong, Yanjie.,Li, Fubin.,Nian, Yin.,Zhou, Zhongmei.,Yang, Runxiang.,...&Chen, Ceshi.(2016).KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway.THERANOSTICS,6(6),875-886.
MLA Kong, Yanjie,et al."KHF16 is a Leading Structure from Cimicifuga foetida that Suppresses Breast Cancer Partially by Inhibiting the NF-kappa B Signaling Pathway".THERANOSTICS 6.6(2016):875-886.
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