| Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events | |
| Volle, Julien1; Yu, Xiaotian2; Sun, Huaying1,4; Tanninen, Stephanie E.1; Insel, Nathan1; Takehara-Nishiuchi, Kaori1,2,3 | |
| 2016-06-14 | |
| 发表期刊 | CELL REPORTS
 |
| 卷号 | 15期号:11页码:2400-2410 |
| 摘要 | The ability to link events that are separated in time is important for extracting meaning from experiences and guiding behavior in the future. This ability likely requires the brain to continue representing events even after they have passed, a process that may involve the prefrontal cortex and takes the form of sustained, event-specific neuron activity. Here, we show that experimentally increasing the activity of excitatory neurons in the medial prefrontal cortex (mPFC) enables rats to associate two stimuli separated by a 750-ms long temporal gap. Learning is accompanied by ramping increases in prefrontal theta and beta rhythms during the interval between stimuli. This ramping activity predicts memory-related behavioral responses on a trial-by-trial basis but is not correlated with the same muscular activity during non-memory conditions. Thus, the enhancement of prefrontal neuron excitability extends the time course of evoked prefrontal network activation and facilitates the formation of associations of temporally disparate, but correlated, events. |
| DOI | 10.1016/j.celrep.2016.05.021 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377776400010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26275 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Univ Toronto, Dept Psychol, Toronto, ON M5S 3G3, Canada 2.Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G3, Canada 3.Univ Toronto, Neurosci Program, Toronto, ON M5S 3G3, Canada 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Volle, Julien,Yu, Xiaotian,Sun, Huaying,et al. Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events[J]. CELL REPORTS,2016,15(11):2400-2410. |
| APA | Volle, Julien,Yu, Xiaotian,Sun, Huaying,Tanninen, Stephanie E.,Insel, Nathan,&Takehara-Nishiuchi, Kaori.(2016).Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events.CELL REPORTS,15(11),2400-2410. |
| MLA | Volle, Julien,et al."Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events".CELL REPORTS 15.11(2016):2400-2410. |
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| 10.1016@j.celrep.201（3515KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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