| Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus | |
Wan, Luo-Sheng1; Nian, Yin2,3 ; Ye, Chen-Jun2,3; Shao, Li-Dong1; Peng, Xing-Rong1; Geng, Chang-An1; Zuo, Zhi-Li1; Li, Xiao-Nian1; Yang, Jian2,3,4; Zhou, Ming2,3,5; Qiu, Ming-Hua1
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| 2016-05-06 | |
| 发表期刊 | ORGANIC LETTERS
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| 卷号 | 18期号:9页码:2166-2169 |
| 摘要 | Euphorbia peplus has been used in traditional medicine to treat asthma and psoriasis. Three highly modified diterpenoids, namely, pepluacetal (1) and pepluanol A-B (2-3), have been isolated and identified from this plant. Compounds 1-3 exhibit unprecedented 5/4/7/3, 5/6/7/3, and 5/5/8/3 ring systems, respectively. Their structures with absolute configurations were determined by spectroscopic analyses, X-ray crystallography, and electronic circular dichroism calculations. Since Kv1.3 is a validated target for the treatment of autoimmune diseases, such as multiple sclerosis, type-1 diabetes, asthma, and psoriasis, Kv1.3 was studied in terms of its response to the new compounds. All three compounds inhibit Kv1.3, with compound 3 being the most effective with an IC50 value of 9.50 mu m. |
| DOI | 10.1021/acs.orglett.6b00787 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375891700056 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26248 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Diease Mech, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Ion Channel Res & Drug Dev Ctr, Kunming 650223, Peoples R China 4.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA 5.Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Wan, Luo-Sheng,Nian, Yin,Ye, Chen-Jun,et al. Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus[J]. ORGANIC LETTERS,2016,18(9):2166-2169. |
| APA | Wan, Luo-Sheng.,Nian, Yin.,Ye, Chen-Jun.,Shao, Li-Dong.,Peng, Xing-Rong.,...&Qiu, Ming-Hua.(2016).Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus.ORGANIC LETTERS,18(9),2166-2169. |
| MLA | Wan, Luo-Sheng,et al."Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus".ORGANIC LETTERS 18.9(2016):2166-2169. |
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