| Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum | |
Hu, Linzhen1,2; Zhang, Yu2 ; Zhu, Hucheng1; Liu, Junjun1; Li, Hua1; Li, Xiao-Nian3; Sun, Weiguang1; Zeng, Junfen4; Xue, Yongbo1; Zhang, Yonghui1
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| 2016-05-06 | |
| 发表期刊 | ORGANIC LETTERS
 |
| 卷号 | 18期号:9页码:2272-2275 |
| 摘要 | Seven filicinic acid-ased meroterpenoids (1-7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein-Barr virus, with EC50 values of 0.57 and 0.49 mu M, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking. |
| DOI | 10.1021/acs.orglett.6b00906 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375891700083 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26244 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan 430022, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Linzhen,Zhang, Yu,Zhu, Hucheng,et al. Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum[J]. ORGANIC LETTERS,2016,18(9):2272-2275. |
| APA | Hu, Linzhen.,Zhang, Yu.,Zhu, Hucheng.,Liu, Junjun.,Li, Hua.,...&Zhang, Yonghui.(2016).Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum.ORGANIC LETTERS,18(9),2272-2275. |
| MLA | Hu, Linzhen,et al."Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum".ORGANIC LETTERS 18.9(2016):2272-2275. |
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| hu2016.pdf（1473KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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