Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum
Hu, Linzhen1,2; Zhang, Yu2; Zhu, Hucheng1; Liu, Junjun1; Li, Hua1; Li, Xiao-Nian3; Sun, Weiguang1; Zeng, Junfen4; Xue, Yongbo1; Zhang, Yonghui1
2016-05-06
Source PublicationORGANIC LETTERS
Volume18Issue:9Pages:2272-2275
AbstractSeven filicinic acid-ased meroterpenoids (1-7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein-Barr virus, with EC50 values of 0.57 and 0.49 mu M, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.
DOI10.1021/acs.orglett.6b00906
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000375891700083
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26244
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan 430022, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Peoples R China
Recommended Citation
GB/T 7714
Hu, Linzhen,Zhang, Yu,Zhu, Hucheng,et al. Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum[J]. ORGANIC LETTERS,2016,18(9):2272-2275.
APA Hu, Linzhen.,Zhang, Yu.,Zhu, Hucheng.,Liu, Junjun.,Li, Hua.,...&Zhang, Yonghui.(2016).Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum.ORGANIC LETTERS,18(9),2272-2275.
MLA Hu, Linzhen,et al."Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum".ORGANIC LETTERS 18.9(2016):2272-2275.
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