Oleanane-type triterpene saponins from Hydrocotyle nepalensis
Ma, Rui-Jing1,2; Liu, Zhen-Hua1,2; Zi, Cheng-Ting3; Gao, Wei4; Dong, Fa-Wu1,2; Yang, Liu1; Li, Jin-Yu1,2; Zhou, Jun1; Hu, Jiang-Miao1
Source PublicationFITOTERAPIA
AbstractFive new oleanane-type triterpene saponins including steganogenin 3-O-beta-D-glucopyranoside (1), steganogenin 3-O-alpha-D-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (2), steganogenin 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (3), chichipegenin 3-O-alpha-D-rhamnopyranosyl-(1 -> 2)-beta-D-glucopyranoside (4) and chichipegenin 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (5), along with four known oleanane-type triterpenes and triterpene saponins (6-9) were isolated from EtOH extract of the whole plant of Hydrocotyle nepalensis. To the best of our knowledge, oleanane-type triterpenes possessing skeleton with 17, 22-seco-backbone (1-3) are not common in natural products. Compound 8 was isolated as a new natural product. The structures of new compounds were elucidated by extensive spectroscopic methods and chemical evidence. Moreover, the cytotoxic activity of all the isolates against five selected human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) was evaluated and the results indicated that compounds 6 and 7 show stronger cytotoxic activity. (C) 2016 Elsevier B.V. All rights reserved.
KeywordHydrocotyle Nepalensis Oleanane-type Triterpene Saponin Cytotoxic Activity
Indexed BySCI
WOS IDWOS:000375739400010
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Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Yunnan Agr Univ, Longrun Pu Er Tea Acad, Kunming 650201, Peoples R China
4.Anhui Univ Tradit Chinese Med, Coll Pharm, Hefei 230038, Peoples R China
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Ma, Rui-Jing,Liu, Zhen-Hua,Zi, Cheng-Ting,et al. Oleanane-type triterpene saponins from Hydrocotyle nepalensis[J]. FITOTERAPIA,2016,110:66-71.
APA Ma, Rui-Jing.,Liu, Zhen-Hua.,Zi, Cheng-Ting.,Gao, Wei.,Dong, Fa-Wu.,...&Hu, Jiang-Miao.(2016).Oleanane-type triterpene saponins from Hydrocotyle nepalensis.FITOTERAPIA,110,66-71.
MLA Ma, Rui-Jing,et al."Oleanane-type triterpene saponins from Hydrocotyle nepalensis".FITOTERAPIA 110(2016):66-71.
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