Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans
Chen, He-Ping1,3; Zhao, Zhen-Zhu1,3; Li, Zheng-Hui1,2; Dong, Ze-Jun1; Wei, Kun1; Bai, Xue1; Zhang, Ling1; Wen, Chun-Nan1,3; Feng, Tao1,2; Liu, Ji-Kai1,2
2016-04-01
Source PublicationCHEMISTRYOPEN
Volume5Issue:2Pages:142-149
AbstractA variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans. In the present study, we describe 16 novel natural oximes and oxime esters with a vibralactone backbone, vibralactoximes, which were isolated from the scale-up fermentation broth of B.vibrans. Their structures were determined through extensive spectroscopic analyses. These compounds represent the first oxime esters from nature. The hypothetical biosynthetic pathway of these compounds was also proposed. Seven compounds exhibited significant pancreatic lipase inhibitory activity, while ten compounds exhibited cytotoxicities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), with IC50 values comparable with those of cisplatin.
KeywordCytotoxicity Natural Products Oximes Oxime Esters Pancreatic Lipase Structure Elucidation
DOI10.1002/open.201500198
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000374711500007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26232
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, He-Ping,Zhao, Zhen-Zhu,Li, Zheng-Hui,et al. Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans[J]. CHEMISTRYOPEN,2016,5(2):142-149.
APA Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,Dong, Ze-Jun.,Wei, Kun.,...&Liu, Ji-Kai.(2016).Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans.CHEMISTRYOPEN,5(2),142-149.
MLA Chen, He-Ping,et al."Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans".CHEMISTRYOPEN 5.2(2016):142-149.
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