| Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans | |
Chen, He-Ping1,3; Zhao, Zhen-Zhu1,3; Li, Zheng-Hui1,2; Dong, Ze-Jun1 ; Wei, Kun1; Bai, Xue1; Zhang, Ling1; Wen, Chun-Nan1,3; Feng, Tao1,2; Liu, Ji-Kai1,2
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| 2016-04-01 | |
| 发表期刊 | CHEMISTRYOPEN
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| 卷号 | 5期号:2页码:142-149 |
| 摘要 | A variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans. In the present study, we describe 16 novel natural oximes and oxime esters with a vibralactone backbone, vibralactoximes, which were isolated from the scale-up fermentation broth of B.vibrans. Their structures were determined through extensive spectroscopic analyses. These compounds represent the first oxime esters from nature. The hypothetical biosynthetic pathway of these compounds was also proposed. Seven compounds exhibited significant pancreatic lipase inhibitory activity, while ten compounds exhibited cytotoxicities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), with IC50 values comparable with those of cisplatin. |
| 关键词 | Cytotoxicity Natural Products Oximes Oxime Esters Pancreatic Lipase Structure Elucidation |
| DOI | 10.1002/open.201500198 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374711500007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26232 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, He-Ping,Zhao, Zhen-Zhu,Li, Zheng-Hui,et al. Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans[J]. CHEMISTRYOPEN,2016,5(2):142-149. |
| APA | Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,Dong, Ze-Jun.,Wei, Kun.,...&Liu, Ji-Kai.(2016).Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans.CHEMISTRYOPEN,5(2),142-149. |
| MLA | Chen, He-Ping,et al."Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans".CHEMISTRYOPEN 5.2(2016):142-149. |
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