| Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans | |
Chen, He-Ping1,3; Zhao, Zhen-Zhu1,3; Li, Zheng-Hui1,2; Dong, Ze-Jun1 ; Wei, Kun1; Bai, Xue1; Zhang, Ling1; Wen, Chun-Nan1,3; Feng, Tao1,2; Liu, Ji-Kai1,2
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| 2016-04-01 | |
| Source Publication | CHEMISTRYOPEN
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| Volume | 5Issue:2Pages:142-149 |
| Abstract | A variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans. In the present study, we describe 16 novel natural oximes and oxime esters with a vibralactone backbone, vibralactoximes, which were isolated from the scale-up fermentation broth of B.vibrans. Their structures were determined through extensive spectroscopic analyses. These compounds represent the first oxime esters from nature. The hypothetical biosynthetic pathway of these compounds was also proposed. Seven compounds exhibited significant pancreatic lipase inhibitory activity, while ten compounds exhibited cytotoxicities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), with IC50 values comparable with those of cisplatin. |
| Keyword | Cytotoxicity Natural Products Oximes Oxime Esters Pancreatic Lipase Structure Elucidation |
| DOI | 10.1002/open.201500198 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000374711500007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/26232 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, He-Ping,Zhao, Zhen-Zhu,Li, Zheng-Hui,et al. Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans[J]. CHEMISTRYOPEN,2016,5(2):142-149. |
| APA | Chen, He-Ping.,Zhao, Zhen-Zhu.,Li, Zheng-Hui.,Dong, Ze-Jun.,Wei, Kun.,...&Liu, Ji-Kai.(2016).Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans.CHEMISTRYOPEN,5(2),142-149. |
| MLA | Chen, He-Ping,et al."Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans".CHEMISTRYOPEN 5.2(2016):142-149. |
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| chen201111116.pdf（1064KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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