| Antioxidant Lignans and Neolignans from Acorus tatarinowii | |
| Lu, Yuanyuan1,2; Xue, Yongbo1; Chen, Shenjie1; Zhu, Hucheng1; Zhang, Jinwen2; Li, Xiao-Nian3; Wang, Jianping1; Liu, JunJun1; Qi, Changxing1; Du, Guang2; Zhang, Yonghui1 | |
| 2016-03-10 | |
| 发表期刊 | SCIENTIFIC REPORTS
 |
| 卷号 | 6 |
| 摘要 | Eleven new lignans and neolignans, named acortatarinowins G-N (1-8), including three pairs of enantiomers (1a/1b-3a/3b) and five optically pure lignans and neolignans (4-8), along with five known analogs (9-14), were isolated from the rhizomes of Acorus tatarinowii Schott. Compounds 1-3 were successfully separated by chiral HPLC to afford 1a/1b-3a/3b. The planar structures of 1-8 were elucidated by extensive spectroscopic analyses including HRESIMS and NMR. Their absolute configurations were determined by analyses of single-crystal X-ray diffraction and a modified Mosher's method, assisted by experimental and calculated electronic circular dichroism (ECD) data. Compounds 1a and 1b were rare 7,8'-epoxy-8,7'-oxyneolignane. Compounds 1-8 were evaluated for their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH) reducing antioxidant power assay. Compound 6, exhibiting strong DPPH radical scavenging capacity with IC50 value of 16.4 +/- 0.22 mu g/mL, could interpret the herbal traditional usage. |
| DOI | 10.1038/srep22909 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371669600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/26008 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei Province, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei Province, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Yuanyuan,Xue, Yongbo,Chen, Shenjie,et al. Antioxidant Lignans and Neolignans from Acorus tatarinowii[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Lu, Yuanyuan.,Xue, Yongbo.,Chen, Shenjie.,Zhu, Hucheng.,Zhang, Jinwen.,...&Zhang, Yonghui.(2016).Antioxidant Lignans and Neolignans from Acorus tatarinowii.SCIENTIFIC REPORTS,6. |
| MLA | Lu, Yuanyuan,et al."Antioxidant Lignans and Neolignans from Acorus tatarinowii".SCIENTIFIC REPORTS 6(2016). |
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| srep22909.pdf（995KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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