Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major
Zhang, Zhi-Jun1,2; Du, Ru-Nan2; He, Juan2; Wu, Xing-De2; Li, Yan2; Li, Rong-Tao1; Zhao, Qin-Shi2
2016-02-01
Source PublicationHELVETICA CHIMICA ACTA
Volume99Issue:2Pages:157-160
AbstractThree new monoterpenoid indole alkaloids, vinmajorines C-E (1-3), along with 18 known analogues (4-21), were isolated from the whole plants of Vinca major. The new structures were elucidated as (5,15,16R,17,19,20,21)-10,17-dimethoxy-21-methyl-18-oxa-5,16-cycloyohimban-19-ol (1), (5,15,16R,17,20,21)-10-methoxy-21-methyl-18-oxa-5,16-cycloyohimban-17-ol (2), and (5,15,16R,17,20,21)-10-methoxy-21-methyl-18-oxa-5,16-cycloyohimban-17-yl acetate (3), respectively, by extensive NMR and MS analysis and comparison with known compounds. Compounds 1-3 were evaluated for their cytotoxic activities against five human cancer cell lines, compounds 1 and 3 showing moderate cytotoxic activities.
KeywordVinca Major Monoterpenoid Indole Alkaloid Vinmajorines C-e Cytotoxic Activity
DOI10.1002/hlca.201500211
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000370326000011
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25967
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhi-Jun,Du, Ru-Nan,He, Juan,et al. Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major[J]. HELVETICA CHIMICA ACTA,2016,99(2):157-160.
APA Zhang, Zhi-Jun.,Du, Ru-Nan.,He, Juan.,Wu, Xing-De.,Li, Yan.,...&Zhao, Qin-Shi.(2016).Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major.HELVETICA CHIMICA ACTA,99(2),157-160.
MLA Zhang, Zhi-Jun,et al."Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major".HELVETICA CHIMICA ACTA 99.2(2016):157-160.
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