| Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major | |
Zhang, Zhi-Jun1,2; Du, Ru-Nan2; He, Juan2; Wu, Xing-De2; Li, Yan2 ; Li, Rong-Tao1; Zhao, Qin-Shi2
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| 2016-02-01 | |
| Source Publication | HELVETICA CHIMICA ACTA
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| Volume | 99Issue:2Pages:157-160 |
| Abstract | Three new monoterpenoid indole alkaloids, vinmajorines C-E (1-3), along with 18 known analogues (4-21), were isolated from the whole plants of Vinca major. The new structures were elucidated as (5,15,16R,17,19,20,21)-10,17-dimethoxy-21-methyl-18-oxa-5,16-cycloyohimban-19-ol (1), (5,15,16R,17,20,21)-10-methoxy-21-methyl-18-oxa-5,16-cycloyohimban-17-ol (2), and (5,15,16R,17,20,21)-10-methoxy-21-methyl-18-oxa-5,16-cycloyohimban-17-yl acetate (3), respectively, by extensive NMR and MS analysis and comparison with known compounds. Compounds 1-3 were evaluated for their cytotoxic activities against five human cancer cell lines, compounds 1 and 3 showing moderate cytotoxic activities. |
| Keyword | Vinca Major Monoterpenoid Indole Alkaloid Vinmajorines C-e Cytotoxic Activity |
| DOI | 10.1002/hlca.201500211 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000370326000011 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/25967 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Zhi-Jun,Du, Ru-Nan,He, Juan,et al. Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major[J]. HELVETICA CHIMICA ACTA,2016,99(2):157-160. |
| APA | Zhang, Zhi-Jun.,Du, Ru-Nan.,He, Juan.,Wu, Xing-De.,Li, Yan.,...&Zhao, Qin-Shi.(2016).Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major.HELVETICA CHIMICA ACTA,99(2),157-160. |
| MLA | Zhang, Zhi-Jun,et al."Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major".HELVETICA CHIMICA ACTA 99.2(2016):157-160. |
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