Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense
Zhu, Yin-Di1,2; Wu, Hai-Feng1,2; Ma, Guo-Xu1,2; Chen, Rong-Chang1,2; Long, Hai-Lin3; Zuo, Zhi-Li4; Luo, Yun1,2; Zhu, Nai-Liang1,2; Hou, Bo4; Xu, Xu-Dong1,2; Sun, Gui-Bo1,2; Yang, Jun-Shan1,2
2016
Source PublicationRSC ADVANCES
Volume6Issue:9Pages:7260-7266
AbstractSix novel flavonoid-triterpene saponin meroterpenoids, clinoposides A-F (1-6), with two unusual skeletons were isolated from Clinopodium chinense. Clinoposides A-F represent a new class of isopentenyl flavonoid saponin. Their structures were determined based on spectroscopic data and chemical methods. The relative and absolute stereochemistries were assigned using a combination of NOESY and ECD. A possible biogenetic pathway for 1-6 is proposed. The protective effects of clinoposides A-F against H2O2-induced H9c2 cardiomyocyte injury were tested, and all compounds exhibited significantly dose-dependent effects, clinoposides B, D and F showed better protective effects as evidence by increased levels of SOD, CAT and GSH-Px but reduced MDA, LDH, caspase-3 and -9 levels.
DOI10.1039/c5ra27485k
Indexed BySCI
Language英语
WOS IDWOS:000369515500046
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25953
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100193, Peoples R China
2.Chinese Acad Med Sci, Beijing 100193, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Yin-Di,Wu, Hai-Feng,Ma, Guo-Xu,et al. Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense[J]. RSC ADVANCES,2016,6(9):7260-7266.
APA Zhu, Yin-Di.,Wu, Hai-Feng.,Ma, Guo-Xu.,Chen, Rong-Chang.,Long, Hai-Lin.,...&Yang, Jun-Shan.(2016).Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense.RSC ADVANCES,6(9),7260-7266.
MLA Zhu, Yin-Di,et al."Clinoposides A-F: meroterpenoids with protective effects on H9c2 cardiomyocyte from Clinopodium chinense".RSC ADVANCES 6.9(2016):7260-7266.
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