| Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys | |
Yang, Jin1,2; Wang, Wei-Guang1; Wu, Hai-Yan1,2; Du, Xue1; Li, Xiao-Nian1; Li, Yan1 ; Pu, Jian-Xin1; Sun, Han-Dong1
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| 2016 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| 卷号 | 79期号:1页码:132-140 |
| 摘要 | Thirty-two enmein-type ent-kaurane diterpenoids, including 13 new compounds, were isolated from the aerial parts of Isodon phyllostachys. Compounds 1 and 2 are the first examples of 3,20:6,20-diepoxyenmein-type ent-kauranoids, and the structures of these new compounds were established mainly by analyzing NMR and HREIMS data. The absolute configurations of 1 and 8 and the relative configuration of 9 were determined using single-crystal X-ray diffraction. Compounds 11, 15, 20, and 21 were active against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), with IC50 values ranging from 1.2 to 5.0 mu M. Compounds 3, 11, 15, 17, 20, 21, 25, and 29 strongly inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values ranging from 0.74 to 4.93 mu M. |
| DOI | 10.1021/acs.jnatprod.5b00802 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000368755000017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25942 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jin,Wang, Wei-Guang,Wu, Hai-Yan,et al. Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):132-140. |
| APA | Yang, Jin.,Wang, Wei-Guang.,Wu, Hai-Yan.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2016).Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys.JOURNAL OF NATURAL PRODUCTS,79(1),132-140. |
| MLA | Yang, Jin,et al."Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys".JOURNAL OF NATURAL PRODUCTS 79.1(2016):132-140. |
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