Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys
Yang, Jin1,2; Wang, Wei-Guang1; Wu, Hai-Yan1,2; Du, Xue1; Li, Xiao-Nian1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2016
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume79Issue:1Pages:132-140
AbstractThirty-two enmein-type ent-kaurane diterpenoids, including 13 new compounds, were isolated from the aerial parts of Isodon phyllostachys. Compounds 1 and 2 are the first examples of 3,20:6,20-diepoxyenmein-type ent-kauranoids, and the structures of these new compounds were established mainly by analyzing NMR and HREIMS data. The absolute configurations of 1 and 8 and the relative configuration of 9 were determined using single-crystal X-ray diffraction. Compounds 11, 15, 20, and 21 were active against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), with IC50 values ranging from 1.2 to 5.0 mu M. Compounds 3, 11, 15, 17, 20, 21, 25, and 29 strongly inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values ranging from 0.74 to 4.93 mu M.
DOI10.1021/acs.jnatprod.5b00802
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000368755000017
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25942
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Jin,Wang, Wei-Guang,Wu, Hai-Yan,et al. Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):132-140.
APA Yang, Jin.,Wang, Wei-Guang.,Wu, Hai-Yan.,Du, Xue.,Li, Xiao-Nian.,...&Sun, Han-Dong.(2016).Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys.JOURNAL OF NATURAL PRODUCTS,79(1),132-140.
MLA Yang, Jin,et al."Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys".JOURNAL OF NATURAL PRODUCTS 79.1(2016):132-140.
Files in This Item: Download All
File Name/Size DocType Version Access License
yang201699.pdf(1386KB) 开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Jin]'s Articles
[Wang, Wei-Guang]'s Articles
[Wu, Hai-Yan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Jin]'s Articles
[Wang, Wei-Guang]'s Articles
[Wu, Hai-Yan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Jin]'s Articles
[Wang, Wei-Guang]'s Articles
[Wu, Hai-Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: yang201699.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.