Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth

doi:10.3390/molecules201219856

	Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth
	Wang, Chunxiang; Ding, Xiao; Feng, Shi-Xiu; Guan, Qiunong; Zhang, Xiao-Ping; Du, Caigan; Di, Ying-Tong; Chen, Tao
	2015-12-01
发表期刊	MOLECULES
卷号	20 期号:12 页码:22565-22577
摘要	The root of Prismatomeris connata has been used in China for centuries as the medicinal herb Huang Gen (HG), but its phytochemicals or active ingredients are not well understood. In this study, we performed chemical analysis of the ethyl acetate fraction of a HG ethanol extract. We thus isolated seven new tetrahydroanthraquinones, prisconnatanones C-I (compounds 1-7) from the root of P. connata and identified their structures using spectroscopic analyses. Their absolute configurations were established by both modified Mosher's and Mo2OAc4 methods, and ORD techniques. Their cytotoxicity was tested in a panel of human lung tumor cells (H1229, HTB179, A549 and H520 cell lines). Prisconnatanone I (7) showed the highest activity, with an IC50 value ranging from 2.7 mu M to 3.9 mu M in the suppression of tumor cell growth, and the others with chelated phenolic hydroxyls exhibited relatively lower activity (IC50: 8-20 mu M). In conclusion, these data suggest that some of the natural tetrahydroanthraquinones in HG are bioactive, and hydroxylation at C-1 significantly increases the cytotoxicity of these compounds against lung tumor cell growth.
关键词	Natural Compound Prismatomeris Connata Tetrahydroanthraquinones Prisconnatanones C-i Hplc-nmr Anti-tumor Activity
DOI	10.3390/molecules201219856
收录类别	SCI
语种	英语
WOS记录号	WOS:000367533400117
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25435
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wang, Chunxiang,Ding, Xiao,Feng, Shi-Xiu,et al. Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth[J]. MOLECULES,2015,20(12):22565-22577.
APA	Wang, Chunxiang.,Ding, Xiao.,Feng, Shi-Xiu.,Guan, Qiunong.,Zhang, Xiao-Ping.,...&Chen, Tao.(2015).Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth.MOLECULES,20(12),22565-22577.
MLA	Wang, Chunxiang,et al."Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth".MOLECULES 20.12(2015):22565-22577.

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