| Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear | |
Peng, Xing-Rong1,2; Wang, Xia1,2; Zhou, Lin1,2; Hou, Bo1,2; Zuo, Zhi-Li1 ; Qiu, Ming-Hua1
| |
| 2015 | |
| 发表期刊 | RSC ADVANCES
 |
| 卷号 | 5期号:115页码:95212-95222 |
| 摘要 | Ganocochlearic acid A (1), a rearranged hexanorlanostane triterpenoid featuring a g-lactone ring and a five-membered carbon ring, and eleven new lanostane triterpenoids (2-12), along with six known analogues (13-18) were isolated from the fruiting bodies of Ganoderma cochlear. Their structures, including absolute configurations, were established on the basis of the MS, NMR, X-ray crystallographic, and ECD analysis. A plausible biosynthetic pathway for 1 was proposed. Compounds 7-9, 11-13 showed moderate cytotoxic activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values ranging from 8 to 30 mM. Compound 4 exhibited relatively potent cytotoxic activity against MCF-7 cells (IC50: 9.15 mu M), compared to the positive control (cisplatin, IC50: 12.7 mu M). |
| DOI | 10.1039/c5ra16796e |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000364906600079 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/25242 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Xing-Rong,Wang, Xia,Zhou, Lin,et al. Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear[J]. RSC ADVANCES,2015,5(115):95212-95222. |
| APA | Peng, Xing-Rong,Wang, Xia,Zhou, Lin,Hou, Bo,Zuo, Zhi-Li,&Qiu, Ming-Hua.(2015).Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear.RSC ADVANCES,5(115),95212-95222. |
| MLA | Peng, Xing-Rong,et al."Ganocochlearic acid A, a rearranged hexanorlanostane triterpenoid, and cytotoxic triterpenoids from the fruiting bodies of Ganoderma cochlear".RSC ADVANCES 5.115(2015):95212-95222. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| peng2015.pdf（1014KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论