| A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation | |
Jiang,Shiyou; Du,Jiacheng; Kong,Qinghua; Li,Chaocui; Li,Yan ; Sun,Handong; Pu,Jianxin; Mao,Bingyu
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| 2015-10-06 | |
| Source Publication | PLOS ONE
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| Volume | 10Issue:10 |
| Abstract | The Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway antagonists. Epistatic analyses suggest that these compounds likely act at the level or downstream of Smoothened (Smo) and upstream of Suppressor of Fused (Sufu). The ent-Kauranoid-treated cells showed elongated cilia, suppressed Smo trafficking to cilia, and mitotic defects, while the triterpene dilactones had no effect on the cilia and ciliary Smo. These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis. |
| DOI | 10.1371/journal.pone.0139830 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000362510300064 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/25186 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Recommended Citation GB/T 7714 | Jiang,Shiyou,Du,Jiacheng,Kong,Qinghua,et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation[J]. PLOS ONE,2015,10(10). |
| APA | Jiang,Shiyou.,Du,Jiacheng.,Kong,Qinghua.,Li,Chaocui.,Li,Yan.,...&Mao,Bingyu.(2015).A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.PLOS ONE,10(10). |
| MLA | Jiang,Shiyou,et al."A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation".PLOS ONE 10.10(2015). |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| pone.0139830.pdf（7288KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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