A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation

doi:10.1371/journal.pone.0139830

	A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
	Jiang,Shiyou; Du,Jiacheng; Kong,Qinghua; Li,Chaocui; Li,Yan; Sun,Handong; Pu,Jianxin; Mao,Bingyu
	2015-10-06
发表期刊	PLOS ONE
卷号	10 期号:10
摘要	The Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway antagonists. Epistatic analyses suggest that these compounds likely act at the level or downstream of Smoothened (Smo) and upstream of Suppressor of Fused (Sufu). The ent-Kauranoid-treated cells showed elongated cilia, suppressed Smo trafficking to cilia, and mitotic defects, while the triterpene dilactones had no effect on the cilia and ciliary Smo. These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis.
DOI	10.1371/journal.pone.0139830
收录类别	SCI
语种	英语
WOS记录号	WOS:000362510300064
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25186
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Jiang,Shiyou,Du,Jiacheng,Kong,Qinghua,et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation[J]. PLOS ONE,2015,10(10).
APA	Jiang,Shiyou.,Du,Jiacheng.,Kong,Qinghua.,Li,Chaocui.,Li,Yan.,...&Mao,Bingyu.(2015).A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.PLOS ONE,10(10).
MLA	Jiang,Shiyou,et al."A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation".PLOS ONE 10.10(2015).

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