A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation
Jiang,Shiyou; Du,Jiacheng; Kong,Qinghua; Li,Chaocui; Li,Yan; Sun,Handong; Pu,Jianxin; Mao,Bingyu
2015-10-06
Source PublicationPLOS ONE
Volume10Issue:10
AbstractThe Hedgehog (Hh) signaling pathway plays important roles in the tumorigenesis of multiple cancers and is a key target for drug discovery. In a screen of natural products extracted from Chinese herbs, we identified eight ent-Kaurane diterpenoids and two triterpene dilactones as novel Hh pathway antagonists. Epistatic analyses suggest that these compounds likely act at the level or downstream of Smoothened (Smo) and upstream of Suppressor of Fused (Sufu). The ent-Kauranoid-treated cells showed elongated cilia, suppressed Smo trafficking to cilia, and mitotic defects, while the triterpene dilactones had no effect on the cilia and ciliary Smo. These ent-Kaurane diterpenoids provide new prototypes of Hh inhibitors, and are valuable probes for deciphering the mechanisms of Smo ciliary transport and ciliogenesis.
DOI10.1371/journal.pone.0139830
Indexed BySCI
Language英语
WOS IDWOS:000362510300064
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25186
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Jiang,Shiyou,Du,Jiacheng,Kong,Qinghua,et al. A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation[J]. PLOS ONE,2015,10(10).
APA Jiang,Shiyou.,Du,Jiacheng.,Kong,Qinghua.,Li,Chaocui.,Li,Yan.,...&Mao,Bingyu.(2015).A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.PLOS ONE,10(10).
MLA Jiang,Shiyou,et al."A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation".PLOS ONE 10.10(2015).
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