Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone

doi:10.1016/j.fitote.2015.06.019

	Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone
	Liu,Lu; Chen,Ying-Ying; Qin,Xu-Jie; Wang,Bei; Jin,Qiong; Liu,Ya-Ping; Luo,Xiao-Dong
	2015-09-01
发表期刊	FITOTERAPIA
卷号	105 页码:160-164
摘要	Three new monoterpenoid indole alkaloids, named normavacurine-21-one (1), 5-hydroxy-19, 20-E-alschomine (2), and 5-hydroxy-19, 20-Z-alschomine (3), together with thirteen known indole alkaloids (4-16) were isolated from the leaves of Alstonia scholaris cultivated in Kunming. Their structures were elucidated on the basis of extensive spectroscopic analysis, as well as by comparison with the reported spectroscopic data. The leaves of A. scholaris cultivated in Kunming, contained picrinine-type alkaloids, scholaricin-type alkaloids and nareline as major alkaloids. New compounds 1-3 might be derived from a common biogenetic precursor (5). Compounds 1,5 and 10 exhibited significant antibacterial activity against Enterococcus faecalis, and 3,9 and 14 against Pseudomonas aeruginosa with an MIC value of 0.781 mu g/mL, while 14 showed moderate activity against Klepsiella pneumonia with an MIC value of 1.56 mu g/mL. (C) 2015 Elsevier B.V. All rights reserved.
关键词	Alstonia Scholaris Apocynaceae Monoterpenoid Indole Alkaloids Antibacterial Activity
DOI	10.1016/j.fitote.2015.06.019
收录类别	SCI
语种	英语
WOS记录号	WOS:000361401500025
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25139
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Liu,Lu,Chen,Ying-Ying,Qin,Xu-Jie,et al. Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone[J]. FITOTERAPIA,2015,105:160-164.
APA	Liu,Lu.,Chen,Ying-Ying.,Qin,Xu-Jie.,Wang,Bei.,Jin,Qiong.,...&Luo,Xiao-Dong.(2015).Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone.FITOTERAPIA,105,160-164.
MLA	Liu,Lu,et al."Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone".FITOTERAPIA 105(2015):160-164.

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