Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties
Di, Lei1; Shi, Yan-Ni1,2; Yan, Yong-Ming1,2; Jiang, Li-Ping2,3; Hou, Bo1; Wang, Xin-Long1; Zuo, Zhi-Li1; Chen, Yong-Bin3; Yang, Cui-Ping3; Cheng, Yong-Xian1
2015
Source PublicationRSC ADVANCES
Volume5Issue:87Pages:70985-70991
AbstractFour pairs of enantiomeric hypoxanthine analogues (1, 2, 5 and 6), two pairs of enantiomeric adenine analogues (3 and 4), two pyrazines, aspongpyrazines A (7) and B (8), and a pair of glycerides ((+)-9 and (-)-9), along with twenty-eight known substances were isolated from the insect Aspongopus chinensis. The structures of the new natural products were assigned by using spectroscopic and computational methods. Chiral HPLC was used to separate the (-)- and (+)-antipodes of 1-6, and 9. Several of the new, A. chinensis derived natural products were found to promote proliferation of neural stem cells (NSCs) at a concentration of 10 mu M.
DOI10.1039/c5ra12920f
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000360445500034
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25121
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
Recommended Citation
GB/T 7714
Di, Lei,Shi, Yan-Ni,Yan, Yong-Ming,et al. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties[J]. RSC ADVANCES,2015,5(87):70985-70991.
APA Di, Lei.,Shi, Yan-Ni.,Yan, Yong-Ming.,Jiang, Li-Ping.,Hou, Bo.,...&Cheng, Yong-Xian.(2015).Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties.RSC ADVANCES,5(87),70985-70991.
MLA Di, Lei,et al."Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties".RSC ADVANCES 5.87(2015):70985-70991.
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