Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng
Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Qiao, Yi-Jun; Yan, Hui; Li, Yan; Wang, Dong; Zh, Hong-Tao; Luo, Huai-Rong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
2015-08-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume78Issue:8Pages:1829-1840
AbstractThe roots of Panax notoginseng, an important Chinese medicinal plant, have been used traditionally in both the raw and processed forms, due to the different chemical constituents and bioactivities found. Thirty-eight dammarane-type triterpenoid saponins were isolated from the steam-processed roots of P. notoginseng, including 18 new substances, namely, notoginsenosides SP1-SP18 (1-18). The structures of 1-18 were determined on the basis of spectroscopic analysis and acidic hydrolysis. The absolute configuration of the hydroxy group at C-24 in 1-4, 19, and 20 was determined in each case by Mo-2(AcO)(4)-induced circular dichroism. The new compounds were found to feature a diversity of highly oxygenated side chains, formed by hydrolysis of the C-20 sugar moiety followed by dehydration, dehydrogenation, epoxidation, hydroxylation, or methoxylation of the main saponins in the raw roots. The new saponins 1, 2, 6-8, 14, and 17 and the known compounds 20-27 showed promoting effects on the differentiation of PC12 cells, at a concentration of 10 mu M.
DOI10.1021/acs.jnatprod.5b00027
Indexed BySCI
Language英语
WOS IDWOS:000360773700005
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/25118
Collection植物化学与西部植物资源持续利用国家重点实验室
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GB/T 7714
Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1829-1840.
APA Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Qiao, Yi-Jun.,Yan, Hui.,...&Zhang, Ying-Jun.(2015).Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng.JOURNAL OF NATURAL PRODUCTS,78(8),1829-1840.
MLA Gu, Cheng-Zhen,et al."Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1829-1840.
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