| Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng | |
Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Qiao, Yi-Jun; Yan, Hui; Li, Yan ; Wang, Dong; Zh, Hong-Tao; Luo, Huai-Rong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
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| 2015-08-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
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| Volume | 78Issue:8Pages:1829-1840 |
| Abstract | The roots of Panax notoginseng, an important Chinese medicinal plant, have been used traditionally in both the raw and processed forms, due to the different chemical constituents and bioactivities found. Thirty-eight dammarane-type triterpenoid saponins were isolated from the steam-processed roots of P. notoginseng, including 18 new substances, namely, notoginsenosides SP1-SP18 (1-18). The structures of 1-18 were determined on the basis of spectroscopic analysis and acidic hydrolysis. The absolute configuration of the hydroxy group at C-24 in 1-4, 19, and 20 was determined in each case by Mo-2(AcO)(4)-induced circular dichroism. The new compounds were found to feature a diversity of highly oxygenated side chains, formed by hydrolysis of the C-20 sugar moiety followed by dehydration, dehydrogenation, epoxidation, hydroxylation, or methoxylation of the main saponins in the raw roots. The new saponins 1, 2, 6-8, 14, and 17 and the known compounds 20-27 showed promoting effects on the differentiation of PC12 cells, at a concentration of 10 mu M. |
| DOI | 10.1021/acs.jnatprod.5b00027 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000360773700005 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/25118 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Recommended Citation GB/T 7714 | Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1829-1840. |
| APA | Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Qiao, Yi-Jun.,Yan, Hui.,...&Zhang, Ying-Jun.(2015).Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng.JOURNAL OF NATURAL PRODUCTS,78(8),1829-1840. |
| MLA | Gu, Cheng-Zhen,et al."Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1829-1840. |
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| gu2015.pdf（1081KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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