Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng

doi:10.1021/acs.jnatprod.5b00027

	Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng
	Gu, Cheng-Zhen; Lv, Jun-Jiang; Zhang, Xiao-Xia; Qiao, Yi-Jun; Yan, Hui; Li, Yan; Wang, Dong; Zh, Hong-Tao; Luo, Huai-Rong; Yang, Chong-Ren; Xu, Min; Zhang, Ying-Jun
	2015-08-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	78 期号:8 页码:1829-1840
摘要	The roots of Panax notoginseng, an important Chinese medicinal plant, have been used traditionally in both the raw and processed forms, due to the different chemical constituents and bioactivities found. Thirty-eight dammarane-type triterpenoid saponins were isolated from the steam-processed roots of P. notoginseng, including 18 new substances, namely, notoginsenosides SP1-SP18 (1-18). The structures of 1-18 were determined on the basis of spectroscopic analysis and acidic hydrolysis. The absolute configuration of the hydroxy group at C-24 in 1-4, 19, and 20 was determined in each case by Mo-2(AcO)(4)-induced circular dichroism. The new compounds were found to feature a diversity of highly oxygenated side chains, formed by hydrolysis of the C-20 sugar moiety followed by dehydration, dehydrogenation, epoxidation, hydroxylation, or methoxylation of the main saponins in the raw roots. The new saponins 1, 2, 6-8, 14, and 17 and the known compounds 20-27 showed promoting effects on the differentiation of PC12 cells, at a concentration of 10 mu M.
DOI	10.1021/acs.jnatprod.5b00027
收录类别	SCI
语种	英语
WOS记录号	WOS:000360773700005
引用统计	被引频次：43[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25118
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Gu, Cheng-Zhen,Lv, Jun-Jiang,Zhang, Xiao-Xia,et al. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(8):1829-1840.
APA	Gu, Cheng-Zhen.,Lv, Jun-Jiang.,Zhang, Xiao-Xia.,Qiao, Yi-Jun.,Yan, Hui.,...&Zhang, Ying-Jun.(2015).Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng.JOURNAL OF NATURAL PRODUCTS,78(8),1829-1840.
MLA	Gu, Cheng-Zhen,et al."Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng".JOURNAL OF NATURAL PRODUCTS 78.8(2015):1829-1840.

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