| Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1 | |
Wang, Hao1,2 ; Geng, Chang-An1; Xu, Hong-Bo1,2; Huang, Xiao-Yan1; Ma, Yun-Bao1; Yang, Cai-Yan1,2; Zhang, Xue-Mei1; Chen, Ji-Jun1
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| 2015-07-01 | |
| 发表期刊 | PLANTA MEDICA
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| 卷号 | 81期号:10页码:847-854 |
| 摘要 | Investigation on the fruits of Melia toosendan afforded seven new lignans (1-7), along with seventeen known compounds (8-24). The structures of the new compounds, involving four neo-lignans (1-4), two sesquilignans (5-6), and a norlignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77% at 1.02 mM according to the assay on HEK293 cell lines in vitro. |
| 关键词 | Melia Toosendan Meliaceae Lignans Mt1 Receptor Agonistic Activity |
| DOI | 10.1055/s-0035-1546127 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357675400010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/24989 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hao,Geng, Chang-An,Xu, Hong-Bo,et al. Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1[J]. PLANTA MEDICA,2015,81(10):847-854. |
| APA | Wang, Hao.,Geng, Chang-An.,Xu, Hong-Bo.,Huang, Xiao-Yan.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2015).Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1.PLANTA MEDICA,81(10),847-854. |
| MLA | Wang, Hao,et al."Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1".PLANTA MEDICA 81.10(2015):847-854. |
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