| Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities | |
Li, Su-Mei1,2,3; Yang, Xian-Wen2; Shen, Yun-Heng2; Feng, Lin4; Wang, Yue-Hu1 ; Zeng, Hua-Wu2; Liu, Xiao-Hua2; Tian, Jun-Mian2; Shi, Ya-Na1; Long, Chun-Lin1,5; Zhang, Wei-Dong2
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| 通讯作者 | long@mail.kib.ac.cn ; wdzhangy@hotmail.com |
| 2008-08-01 | |
| 发表期刊 | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| 卷号 | 69期号:11页码:2200-2204 |
| 摘要 | Chemical examination of the EtOAc extract from the aerial parts of Aeschynanthus bracteatus led to isolation of four phenylethanol glycosides, aeschynanthosides A-D (1-4), and 55 known constituents, including 8 phenylethanoids, 23 phenols, 5 lignans, 7 flavonoids, 9 terpenoids, and 4 others. Their structures were elucidated mainly by detailed spectroscopic studies and comparison with published data. All 59 compounds were isolated for the first time from an Aeschynanthus species. The isolates were also tested for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Aeschynanthoside D (4) and naringenin (41), within the concentration arrange tested (50-100 mu g/mL), showed very weak dose-dependent effects with the inhibition rate of 24.2%, 35.4%, 66.0%, and 9.5%, 40.1%, 65.0%, respectively, relative to positive controls. (C) 2008 Elsevier Ltd. All rights reserved. |
| 关键词 | Aeschynanthus Bracteatus Gesneriaceae Phenylethanoids Aeschynanthosides A-d Raw 264.7 Macrophages Anti-inflammatory No |
| 学科领域 | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytochem.2008.05.012 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000258863100015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/2495 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China 5.Cent Univ Nationalities, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Su-Mei,Yang, Xian-Wen,Shen, Yun-Heng,et al. Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities[J]. PHYTOCHEMISTRY,2008,69(11):2200-2204. |
| APA | Li, Su-Mei.,Yang, Xian-Wen.,Shen, Yun-Heng.,Feng, Lin.,Wang, Yue-Hu.,...&Zhang, Wei-Dong.(2008).Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities.PHYTOCHEMISTRY,69(11),2200-2204. |
| MLA | Li, Su-Mei,et al."Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities".PHYTOCHEMISTRY 69.11(2008):2200-2204. |
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