Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities
Li, Su-Mei1,2,3; Yang, Xian-Wen2; Shen, Yun-Heng2; Feng, Lin4; Wang, Yue-Hu1; Zeng, Hua-Wu2; Liu, Xiao-Hua2; Tian, Jun-Mian2; Shi, Ya-Na1; Long, Chun-Lin1,5; Zhang, Wei-Dong2
2008-08-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号69期号:11页码:2200-2204
摘要Chemical examination of the EtOAc extract from the aerial parts of Aeschynanthus bracteatus led to isolation of four phenylethanol glycosides, aeschynanthosides A-D (1-4), and 55 known constituents, including 8 phenylethanoids, 23 phenols, 5 lignans, 7 flavonoids, 9 terpenoids, and 4 others. Their structures were elucidated mainly by detailed spectroscopic studies and comparison with published data. All 59 compounds were isolated for the first time from an Aeschynanthus species. The isolates were also tested for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Aeschynanthoside D (4) and naringenin (41), within the concentration arrange tested (50-100 mu g/mL), showed very weak dose-dependent effects with the inhibition rate of 24.2%, 35.4%, 66.0%, and 9.5%, 40.1%, 65.0%, respectively, relative to positive controls. (C) 2008 Elsevier Ltd. All rights reserved.
关键词Aeschynanthus Bracteatus Gesneriaceae Phenylethanoids Aeschynanthosides A-d Raw 264.7 Macrophages Anti-inflammatory No
资助信息We acknowledge the Department of Instrumental Analysis of the Second Military Medical University for measuring UV, IR, NMR spectra, and the Shanghai Institute of Organic Chemistry for measuring the optical rotations. We wish to thank Guangwan Hu and Lvliu Zou who helped in collection of plant material. Thanks are also expressed to Professor Heng Li, a botanist at Kunming Institute of Botany, who helped in identification of the plants collected from the fields. This research was supported by the Ministry of Science and Technology of China (Nos. 2004DKA30430, 2005DKA21006), and the Ministry of Education of China through its 111 Project (B08044, CUN 985-3-3).
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2008.05.012
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000258863100015
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2495
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China
5.Cent Univ Nationalities, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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Li, Su-Mei,Yang, Xian-Wen,Shen, Yun-Heng,et al. Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities[J]. PHYTOCHEMISTRY,2008,69(11):2200-2204.
APA Li, Su-Mei.,Yang, Xian-Wen.,Shen, Yun-Heng.,Feng, Lin.,Wang, Yue-Hu.,...&Zhang, Wei-Dong.(2008).Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities.PHYTOCHEMISTRY,69(11),2200-2204.
MLA Li, Su-Mei,et al."Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities".PHYTOCHEMISTRY 69.11(2008):2200-2204.
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