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题名: A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People
作者: Zhao, Fu-Wei1, 2; Luo, Min3; Wang, Yue-Hu1; Li, Ma-Lin3; Tang, Gui-Hua1, 2; Long, Chun-Lin1, 4
刊名: ARCHIVES OF PHARMACAL RESEARCH
关键词: Araceae ; Arisaema decipiens Schott ; () (2R*,3S*,6S*) N,2 Dimethyl 3 hydroxy 6 (9 phenylnonyl) ; Limonoids ; Antitumor activity
英文摘要: A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as ( ) (2R*,3S*,6S*) N,2 dimethyl 3 hydroxy 6 (9 phenylnonyl) piperidine (1), 6 deacetylnimbin (2), 28 deoxonimbolide (3) and nimbin (4) The N methylated derivative (la) of 1 was synthesized Compound 1 exhibited weak inhibitory activity against the MCF 7 cell line, while compound la showed potential inhibitory activity against the MCF 7 cell line with an IC(50) value of 4 6 mu M and weak inhibitory activity against K562 and SK OV 3 cells This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine
出版日期: 2010-11-01
卷号: 33, 期号:11, 页码:1735-1739
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0253-6269
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2401
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Kunming Med Coll, Yunnan Lab Pharmacol Nat Prod, Kunming 650031, Peoples R China
4.Minzu Univ, Coll Life & Environm Sci, Beijing 100081, Peoples R China

Recommended Citation:
Zhao, FW; Luo, M; Wang, YH; Li, ML; Tang, GH; Long, CL.A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People,ARCHIVES OF PHARMACAL RESEARCH,2010,33(11):1735-1739
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