A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People
Zhao, Fu-Wei1,2; Luo, Min3; Wang, Yue-Hu1; Li, Ma-Lin3; Tang, Gui-Hua1,2; Long, Chun-Lin1,4
2010-11-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号33期号:11页码:1735-1739
摘要A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as ( ) (2R*,3S*,6S*) N,2 dimethyl 3 hydroxy 6 (9 phenylnonyl) piperidine (1), 6 deacetylnimbin (2), 28 deoxonimbolide (3) and nimbin (4) The N methylated derivative (la) of 1 was synthesized Compound 1 exhibited weak inhibitory activity against the MCF 7 cell line, while compound la showed potential inhibitory activity against the MCF 7 cell line with an IC(50) value of 4 6 mu M and weak inhibitory activity against K562 and SK OV 3 cells This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine
关键词Araceae Arisaema Decipiens Schott Limonoids () (2r* Antitumor Activity 3s* 6s*) n 2 Dimethyl 3 Hydroxy 6 (9 Phenylnonyl)
资助信息This work was funded by grants from the National Natural Science Foundation of China (No 20972166), the Ministry of Education of China through its 111 & 985 projects (B08044 & MUC 985), the JSPS Asian CORE Program (JSPS/AP/109080), and the Knowledge Innovation Program of the Chinese Academy of Sciences We are grateful to Alex Weiss for editing the English
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s12272.010.1104.6
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000284740000005
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2401
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Kunming Med Coll, Yunnan Lab Pharmacol Nat Prod, Kunming 650031, Peoples R China
4.Minzu Univ, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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Zhao, Fu-Wei,Luo, Min,Wang, Yue-Hu,et al. A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(11):1735-1739.
APA Zhao, Fu-Wei,Luo, Min,Wang, Yue-Hu,Li, Ma-Lin,Tang, Gui-Hua,&Long, Chun-Lin.(2010).A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People.ARCHIVES OF PHARMACAL RESEARCH,33(11),1735-1739.
MLA Zhao, Fu-Wei,et al."A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People".ARCHIVES OF PHARMACAL RESEARCH 33.11(2010):1735-1739.
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