Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function

doi:10.4161/cc.9.14.12406

	Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function
	Xu, Han-Zhang 1; Huang, Ying 1,2; Wu, Ying-Li 1; Zhao, Yong 3; Xiao, Wei-Lie 3; Lin, Qi-Shan 4; Sun, Han-Dong3 ; Dai, Wei 2; Chen, Guo-Qiang 1,5
	2010-07-15
发表期刊	CELL CYCLE
卷号	9 期号:14 页码:2897-2907
摘要	In this study, we report the functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon, a perennial shrub frequently used in Chinese folk medicine for tumor treatment. Pharicin A induces mitotic arrest in leukemia and solid tumor-derived cells identified by their morphology, DNA content and mitotic marker analyses. Pharicin A-induced mitotic arrest is associated with unaligned chromosomes, aberrant BubR1 localization and deregulated spindle checkpoint activation. Pharicin A directly binds to BubR1 in vitro, which is correlated with premature sister chromatid separation in vivo. Pharicin A also induces mitotic arrest in paclitaxel-resistant Jurkat and U2OS cells. Combined, our study strongly suggests that pharicin A represents a novel class of small molecule compounds capable of perturbing mitotic progression and initiating mitotic catastrophe, which merits further preclinical and clinical investigations for cancer drug development.
关键词	Pharicin a Mitotic Arrest Leukemia Tumor Cells Spindle Checkpoint
DOI	10.4161/cc.9.14.12406
收录类别	SCI
语种	英语
WOS记录号	WOS:000281205500039
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23920
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Minist Educ, Dept Pathophysiol,Key Lab Cell Differentiat & Apo, Shanghai 200030, Peoples R China 2.NYU, Dept Environm Med & Pharmacol, Tuxedo Pk, NY USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Yunnan, Peoples R China 4.SUNY Albany, Prote Core Facil, Ctr Funct Genom, Albany, NY 12222 USA 5.Chinese Acad Sci, Inst Hlth Sci Ctr, SJTU SM Shanghai Inst Biol Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xu, Han-Zhang,Huang, Ying,Wu, Ying-Li,et al. Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function[J]. CELL CYCLE,2010,9(14):2897-2907.
APA	Xu, Han-Zhang.,Huang, Ying.,Wu, Ying-Li.,Zhao, Yong.,Xiao, Wei-Lie.,...&Chen, Guo-Qiang.(2010).Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function.CELL CYCLE,9(14),2897-2907.
MLA	Xu, Han-Zhang,et al."Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function".CELL CYCLE 9.14(2010):2897-2907.

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