| Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function | |
Xu, Han-Zhang1; Huang, Ying1,2; Wu, Ying-Li1; Zhao, Yong3; Xiao, Wei-Lie3; Lin, Qi-Shan4; Sun, Han-Dong3 ; Dai, Wei2; Chen, Guo-Qiang1,5
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| 2010-07-15 | |
| 发表期刊 | CELL CYCLE
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| 卷号 | 9期号:14页码:2897-2907 |
| 摘要 | In this study, we report the functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon, a perennial shrub frequently used in Chinese folk medicine for tumor treatment. Pharicin A induces mitotic arrest in leukemia and solid tumor-derived cells identified by their morphology, DNA content and mitotic marker analyses. Pharicin A-induced mitotic arrest is associated with unaligned chromosomes, aberrant BubR1 localization and deregulated spindle checkpoint activation. Pharicin A directly binds to BubR1 in vitro, which is correlated with premature sister chromatid separation in vivo. Pharicin A also induces mitotic arrest in paclitaxel-resistant Jurkat and U2OS cells. Combined, our study strongly suggests that pharicin A represents a novel class of small molecule compounds capable of perturbing mitotic progression and initiating mitotic catastrophe, which merits further preclinical and clinical investigations for cancer drug development. |
| 关键词 | Pharicin a Mitotic Arrest Leukemia Tumor Cells Spindle Checkpoint |
| DOI | 10.4161/cc.9.14.12406 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281205500039 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/23920 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Minist Educ, Dept Pathophysiol,Key Lab Cell Differentiat & Apo, Shanghai 200030, Peoples R China 2.NYU, Dept Environm Med & Pharmacol, Tuxedo Pk, NY USA 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Yunnan, Peoples R China 4.SUNY Albany, Prote Core Facil, Ctr Funct Genom, Albany, NY 12222 USA 5.Chinese Acad Sci, Inst Hlth Sci Ctr, SJTU SM Shanghai Inst Biol Sci, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Han-Zhang,Huang, Ying,Wu, Ying-Li,et al. Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function[J]. CELL CYCLE,2010,9(14):2897-2907. |
| APA | Xu, Han-Zhang.,Huang, Ying.,Wu, Ying-Li.,Zhao, Yong.,Xiao, Wei-Lie.,...&Chen, Guo-Qiang.(2010).Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function.CELL CYCLE,9(14),2897-2907. |
| MLA | Xu, Han-Zhang,et al."Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function".CELL CYCLE 9.14(2010):2897-2907. |
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| cc0914_2897.pdf（3997KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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