Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons

doi:10.1016/j.neulet.2009.06.010

	Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons
	Zhu, Judy T. T.1; Choi, Roy C. Y.1; Xie, Heidi Q.1; Zheng, Ken Y. Z.1; Guo, Ava J. Y.1; Bi, Cathy W. C.1; Lau, David T. W.1; Li, Jun 1; Dong, Tina T. X.1; Lau, Brad W. C.2; Chen, Ji J.3; Tsim, Karl W. K.1
	2009-09-11
发表期刊	NEUROSCIENCE LETTERS
卷号	461 期号:2 页码:172-176
摘要	The toxicity of aggregated P-amyloid (A beta) has been implicated as a critical cause in the development of Alzheimer's disease (AD). Hibifolin, a flavonol glycoside derived from herbal plants, possessed a strong protective activity against cell death induced by aggregated A beta. Application of hibifolin in primary cortical neurons prevented the A beta-induced cell death in a dose-dependent manner. In cultured cortical neurons. the pre-treatment of hibifolin abolished A beta-induced Ca(2+) mobilization, and also reduced A beta-induced caspase-3 and caspase-7 activation. Moreover, DNA fragmentation induced by A beta could be suppressed by hibifolin. In addition to such protection mechanisms, hibifolin was able to induce Akt phosphorylation in cortical neurons, which could be another explanation for the neuroprotection activity. These results therefore provided the first evidence that hibifolin protected neurons against A beta-induced apoptosis and stimulated Akt activation, which would be useful in developing potential drugs or food supplements for treating AD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
关键词	Neuroprotection Cortical Neuron Flavonoid Hibifolin
DOI	10.1016/j.neulet.2009.06.010
收录类别	SCI
语种	英语
WOS记录号	WOS:000268429400024
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23881
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China 2.Macao Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, Taipa, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Judy T. T.,Choi, Roy C. Y.,Xie, Heidi Q.,et al. Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons[J]. NEUROSCIENCE LETTERS,2009,461(2):172-176.
APA	Zhu, Judy T. T..,Choi, Roy C. Y..,Xie, Heidi Q..,Zheng, Ken Y. Z..,Guo, Ava J. Y..,...&Tsim, Karl W. K..(2009).Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons.NEUROSCIENCE LETTERS,461(2),172-176.
MLA	Zhu, Judy T. T.,et al."Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons".NEUROSCIENCE LETTERS 461.2(2009):172-176.

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