Six new C(21) steroidal glycosides from Asclepias curassavica L.

doi:10.1016/j.steroids.2008.01.015

	Six new C(21) steroidal glycosides from Asclepias curassavica L.
	Li, Jun-Zhu; Liu, Hai-Yang; Lin, Yi-Ju; Hao, Xiao-Jiang; Ni, Wei; Chen, Chang-Xiang
	2008-07-01
发表期刊	STEROIDS
卷号	73 期号:6 页码:594-600
摘要	Six new C(21) steroidal glycosides, named curassavosides A-F (3-8), were obtained from the aerial parts of Asclepias curassavica (Asclepiadaceae), along with two known oxypregnanes, 12-O-benzoyldeacylmetaplexigenin (1) and 12-O-benzoylsarcostin (2). By spectroscopic methods, the structures of the six new compounds were determined as 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (3), 12-O-benzoylsarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (4), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (5), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-digitoxopyranoside (6), 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyrano side (7), and 12-O-benzoylsarcostin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (8), respectively. All compounds (1-8) were tested for in vitro cytotoxicity; only compound 3 showed weak inhibitory activity against Raji and AGZY cell lines. (C) 2008 Elsevier Inc. All rights reserved.
关键词	Asclepias Curassavica Asclepiadaceae c(21) Steroidal Glycosides
DOI	10.1016/j.steroids.2008.01.015
收录类别	SCI
语种	英语
WOS记录号	WOS:000255817100003
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23859
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Li, Jun-Zhu,Liu, Hai-Yang,Lin, Yi-Ju,et al. Six new C(21) steroidal glycosides from Asclepias curassavica L.[J]. STEROIDS,2008,73(6):594-600.
APA	Li, Jun-Zhu,Liu, Hai-Yang,Lin, Yi-Ju,Hao, Xiao-Jiang,Ni, Wei,&Chen, Chang-Xiang.(2008).Six new C(21) steroidal glycosides from Asclepias curassavica L..STEROIDS,73(6),594-600.
MLA	Li, Jun-Zhu,et al."Six new C(21) steroidal glycosides from Asclepias curassavica L.".STEROIDS 73.6(2008):594-600.

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