Phytochemical analysis of an antiviral fraction of Radix astragali using HPLC-DAD-ESI-MS/MS
Tang, Li1; Liu, Ying1; Wang, Yeling1; Long, Chunlin1,2
2010-04-01
发表期刊JOURNAL OF NATURAL MEDICINES
ISSN1340-3443
卷号64期号:2页码:182-186
摘要Radix astragali (Huangqi in Chinese) is a well-known traditional Chinese medicinal herb that has been used clinically in China for centuries to cure various diseases. To profile the antiviral constituents of this herb, a high-performance liquid chromatography-diode array detector-electrospray ionization-tandem mass spectrometry (HPLC-DAD-ESI-MS/MS) analytical method was developed to separate and determinate the active part of the extract of Radix astragali, which showed potent inhibition of several viruses. By comparing their retention time and MS data with those obtained from the authentic compounds and the published data, a total of 18 compounds, comprising 11 flavonoids and 7 saponins, were identified. This study provides an approach to rapidly characterize bioactive constituents in traditional Chinese medicines (TCMs).
关键词Radix Astragali Antiviral Activity Flavonoid Saponin Hplc-dad-esi-ms/ms
资助信息This work was supported by Beijing Nova Program (2008118), 985 Project (CUN 985-03-03) and 111Project (B08044).
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2315
专题资源植物与生物技术所级重点实验室
作者单位1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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GB/T 7714
Tang, Li,Liu, Ying,Wang, Yeling,et al. Phytochemical analysis of an antiviral fraction of Radix astragali using HPLC-DAD-ESI-MS/MS[J]. JOURNAL OF NATURAL MEDICINES,2010,64(2):182-186.
APA Tang, Li,Liu, Ying,Wang, Yeling,&Long, Chunlin.(2010).Phytochemical analysis of an antiviral fraction of Radix astragali using HPLC-DAD-ESI-MS/MS.JOURNAL OF NATURAL MEDICINES,64(2),182-186.
MLA Tang, Li,et al."Phytochemical analysis of an antiviral fraction of Radix astragali using HPLC-DAD-ESI-MS/MS".JOURNAL OF NATURAL MEDICINES 64.2(2010):182-186.
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