The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Munich, Dept Chem, D-81377 Munich, Germany
Recommended Citation:
Liu, DZ; Wang, F; Liao, TG; Tang, JG; Steglich, W; Zhu, HJ; Liu, JK.Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans,ORGANIC LETTERS,2006,8(25):5749-5752
