Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans
Liu, Dong-Ze; Wang, Fei; Liao, Tou-Gen; Tang, Jian-Guo; Steglich, Wolfgang; Zhu, Hua-Jie; Liu, Ji-Kai
2006-12-07
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume8Issue:25Pages:5749-5752
AbstractThe structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.
KeywordAb-initio Calculation Optical-rotation Microbial Metabolite Neuroblastoma-cells Stereum-purpureum Lactacystin Tetrahydrolipstatin Orlistat Catalyst Acid
Subject AreaChemistry ; Organic
DOI10.1021/ol062307u
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000242405900018
Citation statistics
Cited Times:127[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2141
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Univ Munich, Dept Chem, D-81377 Munich, Germany
Recommended Citation
GB/T 7714
Liu, Dong-Ze,Wang, Fei,Liao, Tou-Gen,et al. Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans[J]. ORGANIC LETTERS,2006,8(25):5749-5752.
APA Liu, Dong-Ze.,Wang, Fei.,Liao, Tou-Gen.,Tang, Jian-Guo.,Steglich, Wolfgang.,...&Liu, Ji-Kai.(2006).Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.ORGANIC LETTERS,8(25),5749-5752.
MLA Liu, Dong-Ze,et al."Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans".ORGANIC LETTERS 8.25(2006):5749-5752.
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