Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans
Liu, Dong-Ze; Wang, Fei; Liao, Tou-Gen; Tang, Jian-Guo; Steglich, Wolfgang; Zhu, Hua-Jie; Liu, Ji-Kai
2006-12-07
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号8期号:25页码:5749-5752
摘要The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.
关键词Ab-initio Calculation Optical-rotation Microbial Metabolite Neuroblastoma-cells Stereum-purpureum Lactacystin Tetrahydrolipstatin Orlistat Catalyst Acid
学科领域Chemistry ; Organic
DOI10.1021/ol062307u
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000242405900018
引用统计
被引频次:121[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2141
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Univ Munich, Dept Chem, D-81377 Munich, Germany
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Liu, Dong-Ze,Wang, Fei,Liao, Tou-Gen,et al. Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans[J]. ORGANIC LETTERS,2006,8(25):5749-5752.
APA Liu, Dong-Ze.,Wang, Fei.,Liao, Tou-Gen.,Tang, Jian-Guo.,Steglich, Wolfgang.,...&Liu, Ji-Kai.(2006).Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.ORGANIC LETTERS,8(25),5749-5752.
MLA Liu, Dong-Ze,et al."Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans".ORGANIC LETTERS 8.25(2006):5749-5752.
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