| Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans | |
| Liu, Dong-Ze; Wang, Fei; Liao, Tou-Gen; Tang, Jian-Guo; Steglich, Wolfgang; Zhu, Hua-Jie; Liu, Ji-Kai | |
| 2006-12-07 | |
| Source Publication | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| Volume | 8Issue:25Pages:5749-5752 |
| Abstract | The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL. |
| Keyword | Ab-initio Calculation Optical-rotation Microbial Metabolite Neuroblastoma-cells Stereum-purpureum Lactacystin Tetrahydrolipstatin Orlistat Catalyst Acid |
| Subject Area | Chemistry ; Organic |
| DOI | 10.1021/ol062307u |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000242405900018 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/2141 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Munich, Dept Chem, D-81377 Munich, Germany |
| Recommended Citation GB/T 7714 | Liu, Dong-Ze,Wang, Fei,Liao, Tou-Gen,et al. Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans[J]. ORGANIC LETTERS,2006,8(25):5749-5752. |
| APA | Liu, Dong-Ze.,Wang, Fei.,Liao, Tou-Gen.,Tang, Jian-Guo.,Steglich, Wolfgang.,...&Liu, Ji-Kai.(2006).Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.ORGANIC LETTERS,8(25),5749-5752. |
| MLA | Liu, Dong-Ze,et al."Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans".ORGANIC LETTERS 8.25(2006):5749-5752. |
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