Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans

doi:10.1021/ol062307u

	Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans
	Liu, Dong-Ze ; Wang, Fei ; Liao, Tou-Gen ; Tang, Jian-Guo ; Steglich, Wolfgang ; Zhu, Hua-Jie ; Liu, Ji-Kai
	2006-12-07
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	8 期号:25 页码:5749-5752
摘要	The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 mu g/mL.
关键词	Ab-initio Calculation Optical-rotation Microbial Metabolite Neuroblastoma-cells Stereum-purpureum Lactacystin Tetrahydrolipstatin Orlistat Catalyst Acid
学科领域	Chemistry ; Organic
DOI	10.1021/ol062307u
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000242405900018
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2141
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Univ Munich, Dept Chem, D-81377 Munich, Germany
推荐引用方式 GB/T 7714	Liu, Dong-Ze,Wang, Fei,Liao, Tou-Gen,et al. Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans[J]. ORGANIC LETTERS,2006,8(25):5749-5752.
APA	Liu, Dong-Ze.,Wang, Fei.,Liao, Tou-Gen.,Tang, Jian-Guo.,Steglich, Wolfgang.,...&Liu, Ji-Kai.(2006).Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.ORGANIC LETTERS,8(25),5749-5752.
MLA	Liu, Dong-Ze,et al."Vibralactone: A lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans".ORGANIC LETTERS 8.25(2006):5749-5752.

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