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题名: Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma
作者: Liu, Yanchun1; Yang, Hui2; Chen, Tianxing2; Luo, Yongbin1; Xu, Zheyuan3; Li, Ying2; Yang, Jiahui1
刊名: PLOS ONE
出版日期: 2015-05-15
卷号: 10, 期号:5, 页码:e0127092
学科分类: Multidisciplinary Sciences
DOI: 10.1371/journal.pone.0127092
通讯作者: Yang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China. ; yangjiahui@mail.kib.ac.cn
文章类型: Article
英文摘要: Receptor tyrosine kinase ROR1, an embryonic protein involved in organogenesis, is expressed in certain hematological malignancies and solid tumors, but is generally absent in adult tissues. This makes the protein an ideal drug target for cancer therapy. In order to assess the suitability of ROR1 as a cell surface antigen for targeted therapy of lung adenocarcinoma, we carried out a comprehensive analysis of ROR1 protein expression in human lung adenocarcinoma tissues and cell lines. Our data show that ROR1 protein is selectively expressed on lung adenocarcinoma cells, but do not support the hypothesis that expression levels of ROR1 are associated with aggressive disease. However silencing of ROR1 via siRNA treatment significantly down-regulates the activity of the PI3K/AKT/mTOR signaling pathway. This is associated with significant apoptosis and anti-proliferation of tumor cells. We found ROR1 protein expressed in lung adenocarcinoma but almost absent in tumor-adjacent tissues of the patients. The finding of ROR1-mediated proliferation signals in both tyrosine kinase inhibitor (TKI)-sensitive and -resistant tumor cells provides encouragement to develop ROR1-directed targeted therapy in lung adenocarcinoma, especially those with TKI resistance.
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CHRONIC LYMPHOCYTIC-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHIMERIC ANTIGEN RECEPTOR ; CLL CELLS ; MONOCLONAL-ANTIBODIES ; CANCER STATISTICS ; NEVER SMOKERS ; T-CELLS ; EGFR ; MUTATIONS
收录类别: SCI
项目资助者: National Natural Science Foundation of China [81401904] ; Outstanding Talent Projects of Kunming Institute of Botany, Chinese Academy of Sciences
语种: 英语
WOS记录号: WOS:000354916100128
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21356
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.First Peoples Hosp Yunnan Prov, Dept Pathol, Kunming, Yunnan, Peoples R China
3.First Peoples Hosp Yunnan Prov, Dept Thorac Surg, Kunming, Yunnan, Peoples R China
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