Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma
Liu, Yanchun1; Yang, Hui2; Chen, Tianxing2; Luo, Yongbin1; Xu, Zheyuan3; Li, Ying2; Yang, Jiahui1; Yang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; yangjiahui@mail.kib.ac.cn
2015-05-15
Source PublicationPLOS ONE
Volume10Issue:5Pages:e0127092
AbstractReceptor tyrosine kinase ROR1, an embryonic protein involved in organogenesis, is expressed in certain hematological malignancies and solid tumors, but is generally absent in adult tissues. This makes the protein an ideal drug target for cancer therapy. In order to assess the suitability of ROR1 as a cell surface antigen for targeted therapy of lung adenocarcinoma, we carried out a comprehensive analysis of ROR1 protein expression in human lung adenocarcinoma tissues and cell lines. Our data show that ROR1 protein is selectively expressed on lung adenocarcinoma cells, but do not support the hypothesis that expression levels of ROR1 are associated with aggressive disease. However silencing of ROR1 via siRNA treatment significantly down-regulates the activity of the PI3K/AKT/mTOR signaling pathway. This is associated with significant apoptosis and anti-proliferation of tumor cells. We found ROR1 protein expressed in lung adenocarcinoma but almost absent in tumor-adjacent tissues of the patients. The finding of ROR1-mediated proliferation signals in both tyrosine kinase inhibitor (TKI)-sensitive and -resistant tumor cells provides encouragement to develop ROR1-directed targeted therapy in lung adenocarcinoma, especially those with TKI resistance.
Subject AreaMultidisciplinary Sciences
DOI10.1371/journal.pone.0127092
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000354916100128
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21356
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorYang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; yangjiahui@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.First Peoples Hosp Yunnan Prov, Dept Pathol, Kunming, Yunnan, Peoples R China
3.First Peoples Hosp Yunnan Prov, Dept Thorac Surg, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanchun,Yang, Hui,Chen, Tianxing,et al. Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma[J]. PLOS ONE,2015,10(5):e0127092.
APA Liu, Yanchun.,Yang, Hui.,Chen, Tianxing.,Luo, Yongbin.,Xu, Zheyuan.,...&yangjiahui@mail.kib.ac.cn.(2015).Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma.PLOS ONE,10(5),e0127092.
MLA Liu, Yanchun,et al."Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma".PLOS ONE 10.5(2015):e0127092.
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