Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma
Liu, Yanchun1; Yang, Hui2; Chen, Tianxing2; Luo, Yongbin1; Xu, Zheyuan3; Li, Ying2; Yang, Jiahui1; Yang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; yangjiahui@mail.kib.ac.cn
2015-05-15
发表期刊PLOS ONE
卷号10期号:5页码:e0127092
摘要Receptor tyrosine kinase ROR1, an embryonic protein involved in organogenesis, is expressed in certain hematological malignancies and solid tumors, but is generally absent in adult tissues. This makes the protein an ideal drug target for cancer therapy. In order to assess the suitability of ROR1 as a cell surface antigen for targeted therapy of lung adenocarcinoma, we carried out a comprehensive analysis of ROR1 protein expression in human lung adenocarcinoma tissues and cell lines. Our data show that ROR1 protein is selectively expressed on lung adenocarcinoma cells, but do not support the hypothesis that expression levels of ROR1 are associated with aggressive disease. However silencing of ROR1 via siRNA treatment significantly down-regulates the activity of the PI3K/AKT/mTOR signaling pathway. This is associated with significant apoptosis and anti-proliferation of tumor cells. We found ROR1 protein expressed in lung adenocarcinoma but almost absent in tumor-adjacent tissues of the patients. The finding of ROR1-mediated proliferation signals in both tyrosine kinase inhibitor (TKI)-sensitive and -resistant tumor cells provides encouragement to develop ROR1-directed targeted therapy in lung adenocarcinoma, especially those with TKI resistance.
资助信息National Natural Science Foundation of China [81401904]; Outstanding Talent Projects of Kunming Institute of Botany, Chinese Academy of Sciences
学科领域Multidisciplinary Sciences
DOI10.1371/journal.pone.0127092
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000354916100128
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21356
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Yang,JH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming,Yunnan,Peoples R China.; yangjiahui@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.First Peoples Hosp Yunnan Prov, Dept Pathol, Kunming, Yunnan, Peoples R China
3.First Peoples Hosp Yunnan Prov, Dept Thorac Surg, Kunming, Yunnan, Peoples R China
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Liu, Yanchun,Yang, Hui,Chen, Tianxing,et al. Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma[J]. PLOS ONE,2015,10(5):e0127092.
APA Liu, Yanchun.,Yang, Hui.,Chen, Tianxing.,Luo, Yongbin.,Xu, Zheyuan.,...&yangjiahui@mail.kib.ac.cn.(2015).Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma.PLOS ONE,10(5),e0127092.
MLA Liu, Yanchun,et al."Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma".PLOS ONE 10.5(2015):e0127092.
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