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题名: 4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses
作者: Cui, Yanli; Li, Zhiyuan; Cheng, Zhaodong; null(夏成峰); Zhang, Yongmin
刊名: CHEMICAL RESEARCH IN TOXICOLOGY
英文摘要: The total synthesis of 4,5-cis unsaturated alpha-GalCer analogues was achieved, and their immune-response altering activity was assessed in vitro as well as in vivo in mice. Using glycosyl iodide as a glycosyl donor, construction of the sphingosine unit was shortened by four steps and single alpha-stereoselectivity was achieved in good yield (67%). With regard to the therapeutic use of alpha-GalCer, the novel analogues (1b and 1c) distinctly induced a Th1-biased cytokine response, avoiding induction of a contradictory response and overstimulation.
出版日期: 2015-06-01
卷号: 28, 期号:6, 页码:1209-1215
DOI标识: 10.1021/acs.chemrestox.5b00047
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21352
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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