4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses
Cui, Yanli; Li, Zhiyuan; Cheng, Zhaodong; Xia, Chengfeng; Zhang, Yongmin; Cui,YL (reprint author),Zhejiang Univ,Dept Chem,Hangzhou 310027,Peoples R China.; hnzzcyl@hotmail.com; xiachengfeng@mail.kib.ac.cn; yongmin.zhang@ipcm.upmc.fr
2015-06-01
发表期刊CHEMICAL RESEARCH IN TOXICOLOGY
卷号28期号:6页码:1209-1215
摘要The total synthesis of 4,5-cis unsaturated alpha-GalCer analogues was achieved, and their immune-response altering activity was assessed in vitro as well as in vivo in mice. Using glycosyl iodide as a glycosyl donor, construction of the sphingosine unit was shortened by four steps and single alpha-stereoselectivity was achieved in good yield (67%). With regard to the therapeutic use of alpha-GalCer, the novel analogues (1b and 1c) distinctly induced a Th1-biased cytokine response, avoiding induction of a contradictory response and overstimulation.
资助信息National Natural Science Foundation of China [30870553]; International Science & Technology Cooperation Program of China [2010DFA34370]; International S&T Cooperation Program of Zhejiang [2013C14012]; Yunnan High-End Technology Professionals Introduction Program [2010CI117]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21352
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Cui,YL (reprint author),Zhejiang Univ,Dept Chem,Hangzhou 310027,Peoples R China.; hnzzcyl@hotmail.com; xiachengfeng@mail.kib.ac.cn; yongmin.zhang@ipcm.upmc.fr
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Cui, Yanli,Li, Zhiyuan,Cheng, Zhaodong,et al. 4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2015,28(6):1209-1215.
APA Cui, Yanli.,Li, Zhiyuan.,Cheng, Zhaodong.,Xia, Chengfeng.,Zhang, Yongmin.,...&yongmin.zhang@ipcm.upmc.fr.(2015).4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses.CHEMICAL RESEARCH IN TOXICOLOGY,28(6),1209-1215.
MLA Cui, Yanli,et al."4,5-Cis Unsaturated alpha-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses".CHEMICAL RESEARCH IN TOXICOLOGY 28.6(2015):1209-1215.
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