| Antibacterial constituents from Melodinus suaveolens | |
| Li, J. L.; Lunga, P. K.; Zhao, Y. L.; Qin, X. J.; Luo, X. D.; Liu,YP (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; xdluo@mail.kib.ac.cn; liuyap-ing@mail.kib.ac.cn | |
| 2015 | |
| 发表期刊 | CHINESE JOURNAL OF NATURAL MEDICINES
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| 卷号 | 13期号:4页码:307-310 |
| 摘要 | To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopic data, as well as on the basis of extensive spectroscopic analysis. The antibacterial screening assays were performed by the dilution method. Fourteen compounds were isolated, and identified as lycopersene (1). betulinic aldehyde (2), 3 beta-acctoxy-22,23,24,25,26,27-hexanordammaran-20-one(3), 3a-acetyl-2, 3, 5-trimethyl-7a-hydroxy-5-(4,8, 12-trimethyl-tridecanyl)-1,3a, 5,6,7,7a-hexahydro- 4-oxainden-1-one (4), 3 beta-hydroxy-28-norlup-20(29)-ene-17 beta-hydroperoxide (5), 3 beta-hydroxy-28-norlup-20(29)-ene-17 alpha-hydroperoxide (6), beta-sitosterol (7), 28-nor-urs-12-ene-3 beta, 17 beta-diol (8), alpha-amyrin (9), ergosta-4,6,8(14) 22-tetraen-3-one (10), 3 beta-hydroxy-urs-11-en-28,13 beta-olide (11), betulin (12), obtusalin (13), and ursolic acid (14), Among the isolates,. compounds 1, 2. 6, 8, 10, and 14 showed potent antibacterial activities against the four bacteria, This is the first report of the antibacterial activity of the constituents of Melodinus suaveolens |
| 关键词 | Melodinus Suaveolens Apocynaceae Non-alkaloidal Chemical Constituents Meningitis Antibacterial Activity |
| 学科领域 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| DOI | 10.3724/SP.J.1009.2015.00307 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366434900009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21348 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Liu,YP (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; xdluo@mail.kib.ac.cn; liuyap-ing@mail.kib.ac.cn |
| 作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, J. L.,Lunga, P. K.,Zhao, Y. L.,et al. Antibacterial constituents from Melodinus suaveolens[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(4):307-310. |
| APA | Li, J. L..,Lunga, P. K..,Zhao, Y. L..,Qin, X. J..,Luo, X. D..,...&liuyap-ing@mail.kib.ac.cn.(2015).Antibacterial constituents from Melodinus suaveolens.CHINESE JOURNAL OF NATURAL MEDICINES,13(4),307-310. |
| MLA | Li, J. L.,et al."Antibacterial constituents from Melodinus suaveolens".CHINESE JOURNAL OF NATURAL MEDICINES 13.4(2015):307-310. |
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