Antibacterial constituents from Melodinus suaveolens
Li, J. L.; Lunga, P. K.; Zhao, Y. L.; Qin, X. J.; Luo, X. D.; Liu,YP (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; xdluo@mail.kib.ac.cn; liuyap-ing@mail.kib.ac.cn
2015
发表期刊CHINESE JOURNAL OF NATURAL MEDICINES
卷号13期号:4页码:307-310
摘要To investigate the non-alkaloidal chemical constituents of the stems and leaves of Melodinus suaveolens and their antibacterial activities. Compounds were isolated and purified by repeated silica gel, Sephadex LH-20, RP18, and preparative HPLC. Their structures were elucidated by comparison with published spectroscopic data, as well as on the basis of extensive spectroscopic analysis. The antibacterial screening assays were performed by the dilution method. Fourteen compounds were isolated, and identified as lycopersene (1). betulinic aldehyde (2), 3 beta-acctoxy-22,23,24,25,26,27-hexanordammaran-20-one(3), 3a-acetyl-2, 3, 5-trimethyl-7a-hydroxy-5-(4,8, 12-trimethyl-tridecanyl)-1,3a, 5,6,7,7a-hexahydro- 4-oxainden-1-one (4), 3 beta-hydroxy-28-norlup-20(29)-ene-17 beta-hydroperoxide (5), 3 beta-hydroxy-28-norlup-20(29)-ene-17 alpha-hydroperoxide (6), beta-sitosterol (7), 28-nor-urs-12-ene-3 beta, 17 beta-diol (8), alpha-amyrin (9), ergosta-4,6,8(14) 22-tetraen-3-one (10), 3 beta-hydroxy-urs-11-en-28,13 beta-olide (11), betulin (12), obtusalin (13), and ursolic acid (14), Among the isolates,. compounds 1, 2. 6, 8, 10, and 14 showed potent antibacterial activities against the four bacteria, This is the first report of the antibacterial activity of the constituents of Melodinus suaveolens
关键词Melodinus Suaveolens Apocynaceae Non-alkaloidal Chemical Constituents Meningitis Antibacterial Activity
资助信息Natural Science Foundation of China [81225024]; National Science and Technology Support Program of China [2013BAI11B02]
学科领域Integrative & Complementary Medicine ; Pharmacology & Pharmacy
DOI10.3724/SP.J.1009.2015.00307
收录类别SCI
语种英语
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS类目Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000366434900009
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21348
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu,YP (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; xdluo@mail.kib.ac.cn; liuyap-ing@mail.kib.ac.cn
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Li, J. L.,Lunga, P. K.,Zhao, Y. L.,et al. Antibacterial constituents from Melodinus suaveolens[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2015,13(4):307-310.
APA Li, J. L..,Lunga, P. K..,Zhao, Y. L..,Qin, X. J..,Luo, X. D..,...&liuyap-ing@mail.kib.ac.cn.(2015).Antibacterial constituents from Melodinus suaveolens.CHINESE JOURNAL OF NATURAL MEDICINES,13(4),307-310.
MLA Li, J. L.,et al."Antibacterial constituents from Melodinus suaveolens".CHINESE JOURNAL OF NATURAL MEDICINES 13.4(2015):307-310.
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