Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi
Yang, Xing-Wei1,4; Li, Ming-Min1; Liu, Xia1,4; Ferreira, Daneel2; Ding, Yuanqing3; Zhang, Jing-Jing1,4; Liao, Yang1,4; Qin, Hong-Bo1; Xu, Gang1
2015-04-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume78Issue:4Pages:885-895
Abstract

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structural and bioactive diversity. In a systematic phytochemical investigation of Hypericum henryi, 40 PPAP-type derivatives, including the new compounds hyphenrones G-Q, were obtained. These compounds represent 12 different structural types, including four unusual skeletons exemplified by 5, 8, 10, and 17. The 12 different core structures found are explicable in terms of their biosynthetic origin. The structure of a known PPAP, perforatumone, was revised to hyphenrone A (5) by NMR spectroscopic and biomimetic synthesis methods. Several compounds exhibited inhibitory activities against acetylcholinesterase and human tumor cell lines. This study deals with the structural diversity, function, and biogenesis of natural PPAPs.

Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/acs.jnatprod.5b00057
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000353665100037
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21347
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQin, Hong-Bo; Xu, Gang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Mississippi, Sch Pharm, Div Pharmacognosy, Dept Biomol Sci, University, MS 38677 USA
3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xing-Wei,Li, Ming-Min,Liu, Xia,et al. Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(4):885-895.
APA Yang, Xing-Wei.,Li, Ming-Min.,Liu, Xia.,Ferreira, Daneel.,Ding, Yuanqing.,...&Xu, Gang.(2015).Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.JOURNAL OF NATURAL PRODUCTS,78(4),885-895.
MLA Yang, Xing-Wei,et al."Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi".JOURNAL OF NATURAL PRODUCTS 78.4(2015):885-895.
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