Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi
Yang, Xing-Wei1,4; Li, Ming-Min1; Liu, Xia1,4; Ferreira, Daneel2; Ding, Yuanqing3; Zhang, Jing-Jing1,4; Liao, Yang1,4; Qin, Hong-Bo1; Xu, Gang1
2015-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:4页码:885-895
摘要

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structural and bioactive diversity. In a systematic phytochemical investigation of Hypericum henryi, 40 PPAP-type derivatives, including the new compounds hyphenrones G-Q, were obtained. These compounds represent 12 different structural types, including four unusual skeletons exemplified by 5, 8, 10, and 17. The 12 different core structures found are explicable in terms of their biosynthetic origin. The structure of a known PPAP, perforatumone, was revised to hyphenrone A (5) by NMR spectroscopic and biomimetic synthesis methods. Several compounds exhibited inhibitory activities against acetylcholinesterase and human tumor cell lines. This study deals with the structural diversity, function, and biogenesis of natural PPAPs.

资助信息National Natural Sciences Foundation of China [20972167]; Young Academic Leader Raising Foundation of Yunnan Province [2009CI073]; National Science and Technology Support Program of China [2013BAI11B02]; Chinese Academy of Sciences; Program of
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21347
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qin, Hong-Bo; Xu, Gang
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Mississippi, Sch Pharm, Div Pharmacognosy, Dept Biomol Sci, University, MS 38677 USA
3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Res Inst Pharmaceut Sci, University, MS 38677 USA
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yang, Xing-Wei,Li, Ming-Min,Liu, Xia,et al. Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(4):885-895.
APA Yang, Xing-Wei.,Li, Ming-Min.,Liu, Xia.,Ferreira, Daneel.,Ding, Yuanqing.,...&Xu, Gang.(2015).Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.JOURNAL OF NATURAL PRODUCTS,78(4),885-895.
MLA Yang, Xing-Wei,et al."Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi".JOURNAL OF NATURAL PRODUCTS 78.4(2015):885-895.
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