| Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear alpha-Substituted Monothiomalonates with Isatin N-Boc Ketimines | |
| Liu, Teng1; Liu, Weiwei1; Li, Xiaonian2; Peng, Fangzhi1; Shao, Zhihui1; Peng,FZ (reprint author),Yunnan Univ,Sch Chem Sci & Technol,Minist Educ,Key Lab Med Chem Nat Resource,Kunming 650091,Peoples R China.; pengfangzhi@ynu.edu.cn; zhihui_shao@hotmail.com | |
| 2015-05-15 | |
| 发表期刊 | JOURNAL OF ORGANIC CHEMISTRY
 |
| 卷号 | 80期号:10页码:4950-4956 |
| 摘要 | A highly diastereo- and enantioselective method for the construction of vicinal tetrasubstituted stereocenters through the first catalytic asymmetric Mannich reaction of linear a-substituted MTMs with isatin N-Boc ketimines has been developed. This protocol provides atom-economic synthesis of less accessible 3-aminooxindoles bearing vicinal tetrasubstituted stereocenters. Notably, it also constitutes the first example of stereoselective synthesis of beta-amino thioesters bearing vicinal tetrasubstituted stereocenters. |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/acs.joc.5b00302 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354908500011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21346 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Peng,FZ (reprint author),Yunnan Univ,Sch Chem Sci & Technol,Minist Educ,Key Lab Med Chem Nat Resource,Kunming 650091,Peoples R China.; pengfangzhi@ynu.edu.cn; zhihui_shao@hotmail.com |
| 作者单位 | 1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Teng,Liu, Weiwei,Li, Xiaonian,et al. Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear alpha-Substituted Monothiomalonates with Isatin N-Boc Ketimines[J]. JOURNAL OF ORGANIC CHEMISTRY,2015,80(10):4950-4956. |
| APA | Liu, Teng.,Liu, Weiwei.,Li, Xiaonian.,Peng, Fangzhi.,Shao, Zhihui.,...&zhihui_shao@hotmail.com.(2015).Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear alpha-Substituted Monothiomalonates with Isatin N-Boc Ketimines.JOURNAL OF ORGANIC CHEMISTRY,80(10),4950-4956. |
| MLA | Liu, Teng,et al."Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear alpha-Substituted Monothiomalonates with Isatin N-Boc Ketimines".JOURNAL OF ORGANIC CHEMISTRY 80.10(2015):4950-4956. |
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| acs.joc.5b00302.pdf（1183KB） | 开放获取 | CC BY-NC-ND | 浏览 下载 | |||
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