A highly diastereo- and enantioselective method for the construction of vicinal tetrasubstituted stereocenters through the first catalytic asymmetric Mannich reaction of linear a-substituted MTMs with isatin N-Boc ketimines has been developed. This protocol provides atom-economic synthesis of less accessible 3-aminooxindoles bearing vicinal tetrasubstituted stereocenters. Notably, it also constitutes the first example of stereoselective synthesis of beta-amino thioesters bearing vicinal tetrasubstituted stereocenters.
NSFC [21162034, 21372193, 21362040]
; Program for Changjiang Scholars and Innovative Research Team in University [IRT13095]
; Ministry of Education of China 
; Government of the Yunnan Province [2012FB114, 2013FA026]
; Program for Excellent Young Talents, Yunnan University