| Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata | |
Fang, Xin1; Di, Ying Tong1; Zhang, Yu1 ; Xu, Zhi Ping3; Lu, Yang2; Chen, Qian Qian2; Zheng, Qi Tai2; Hao, Xiao Jiang1; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
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| 2015-05-04 | |
| 发表期刊 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 卷号 | 54期号:19页码:5592-5595 |
| 摘要 | Perforalactone A (1), a new 20S quassinoid with a unique cagelike 2,4-dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X-ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid-type natural products are also discussed. |
| 关键词 | Biosynthetic Pathways Insecticidal Activity Natural Products Nicotinic Acetylcholine Receptors Structure Elucidation |
| 学科领域 | Chemistry, Multidisciplinary |
| DOI | 10.1002/anie.201412126 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354193300010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21342 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Xin,Di, Ying Tong,Zhang, Yu,et al. Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(19):5592-5595. |
| APA | Fang, Xin.,Di, Ying Tong.,Zhang, Yu.,Xu, Zhi Ping.,Lu, Yang.,...&haoxj@mail.kib.ac.cn.(2015).Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(19),5592-5595. |
| MLA | Fang, Xin,et al."Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.19(2015):5592-5595. |
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