Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata
Fang, Xin1; Di, Ying Tong1; Zhang, Yu1; Xu, Zhi Ping3; Lu, Yang2; Chen, Qian Qian2; Zheng, Qi Tai2; Hao, Xiao Jiang1; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
2015-05-04
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume54Issue:19Pages:5592-5595
AbstractPerforalactone A (1), a new 20S quassinoid with a unique cagelike 2,4-dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X-ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid-type natural products are also discussed.
KeywordBiosynthetic Pathways Insecticidal Activity Natural Products Nicotinic Acetylcholine Receptors Structure Elucidation
Subject AreaChemistry, Multidisciplinary
DOI10.1002/anie.201412126
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000354193300010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21342
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
Recommended Citation
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Fang, Xin,Di, Ying Tong,Zhang, Yu,et al. Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(19):5592-5595.
APA Fang, Xin.,Di, Ying Tong.,Zhang, Yu.,Xu, Zhi Ping.,Lu, Yang.,...&haoxj@mail.kib.ac.cn.(2015).Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(19),5592-5595.
MLA Fang, Xin,et al."Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.19(2015):5592-5595.
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