Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata
Fang, Xin1; Di, Ying Tong1; Zhang, Yu1; Xu, Zhi Ping3; Lu, Yang2; Chen, Qian Qian2; Zheng, Qi Tai2; Hao, Xiao Jiang1; Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
2015-05-04
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷号54期号:19页码:5592-5595
摘要Perforalactone A (1), a new 20S quassinoid with a unique cagelike 2,4-dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X-ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid-type natural products are also discussed.
关键词Biosynthetic Pathways Insecticidal Activity Natural Products Nicotinic Acetylcholine Receptors Structure Elucidation
资助信息National Science Foundation of China [21432010]; Science Foundation of Yunnan [2014A050]; Technological leading talent project of Yunnan; Xibuzhiguang Project
学科领域Chemistry, Multidisciplinary
DOI10.1002/anie.201412126
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000354193300010
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21342
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; haoxj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
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Fang, Xin,Di, Ying Tong,Zhang, Yu,et al. Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(19):5592-5595.
APA Fang, Xin.,Di, Ying Tong.,Zhang, Yu.,Xu, Zhi Ping.,Lu, Yang.,...&haoxj@mail.kib.ac.cn.(2015).Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(19),5592-5595.
MLA Fang, Xin,et al."Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.19(2015):5592-5595.
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