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题名: Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata
作者: Fang, Xin1; Di, Ying Tong1; Zhang, Yu1; Xu, Zhi Ping3; Lu, Yang2; Chen, Qian Qian2; Zheng, Qi Tai2; null(郝小江)1
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版日期: 2015-05-04
卷号: 54, 期号:19, 页码:5592-5595
关键词: biosynthetic pathways ; insecticidal activity ; natural products ; nicotinic acetylcholine receptors ; structure elucidation
学科分类: Chemistry, Multidisciplinary
DOI: 10.1002/anie.201412126
通讯作者: Hao,XJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; haoxj@mail.kib.ac.cn
文章类型: Article
英文摘要: Perforalactone A (1), a new 20S quassinoid with a unique cagelike 2,4-dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X-ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid-type natural products are also discussed.
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: NICOTINIC ACETYLCHOLINE-RECEPTOR ; ABSOLUTE-STRUCTURE ; NATURAL-PRODUCTS ; METABOLITES ; GROWTH
收录类别: SCI
项目资助者: National Science Foundation of China [21432010] ; Science Foundation of Yunnan [2014A050] ; Technological leading talent project of Yunnan ; Xibuzhiguang Project
语种: 英语
WOS记录号: WOS:000354193300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21342
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
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