| Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities | |
| Yan, Yong-Ming1,2; Li, Li-Ji3; Qin, Xiao-Chu4,5; Lu, Qing1; Tu, Zheng-Chao4,5; Cheng, Yong-Xian1; Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; yxcheng@mail.kib.ac.cn | |
| 2015-06-15 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 卷号 | 25期号:12页码:2469-2472 |
| 摘要 | Blapsols A-D (1-4), four new compounds possessing a 2,3-dihydrobenzo[b][1,4]dioxin group, together with five known N-acetyldopamine dimers (5-9), were isolated from Blaps japanensis. Their structures including the absolute configuration of (+)-1 were determined by means of spectroscopic and X-ray crystallographic methods. Chiral HPLC was used to separate (-)- and (+)-enantiomers of compounds 1-4, which were isolated from this insect as racemic mixtures. All the compounds were found to have inhibitory effects towards COX-2 with IC50 values in the range of 1.3-17.8 mu M. (C) 2015 Elsevier Ltd. All rights reserved. |
| 关键词 | Blaps Japanensis Insects N-acetyldopamine Dimers Cox-1 Cox-2 |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| DOI | 10.1016/j.bmcl.2015.04.085 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355147300002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/21333 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; yxcheng@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Inst Med Sci, Kunming 650011, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Yong-Ming,Li, Li-Ji,Qin, Xiao-Chu,et al. Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(12):2469-2472. |
| APA | Yan, Yong-Ming.,Li, Li-Ji.,Qin, Xiao-Chu.,Lu, Qing.,Tu, Zheng-Chao.,...&yxcheng@mail.kib.ac.cn.(2015).Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(12),2469-2472. |
| MLA | Yan, Yong-Ming,et al."Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.12(2015):2469-2472. |
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