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题名: Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities
作者: Yan, Yong-Ming1, 2; Li, Li-Ji3; Qin, Xiao-Chu4, 5; Lu, Qing1; Tu, Zheng-Chao4, 5; null(程永现)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Blaps japanensis ; Insects ; N-Acetyldopamine dimers ; COX-1 ; COX-2
英文摘要: Blapsols A-D (1-4), four new compounds possessing a 2,3-dihydrobenzo[b][1,4]dioxin group, together with five known N-acetyldopamine dimers (5-9), were isolated from Blaps japanensis. Their structures including the absolute configuration of (+)-1 were determined by means of spectroscopic and X-ray crystallographic methods. Chiral HPLC was used to separate (-)- and (+)-enantiomers of compounds 1-4, which were isolated from this insect as racemic mixtures. All the compounds were found to have inhibitory effects towards COX-2 with IC50 values in the range of 1.3-17.8 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
出版日期: 2015-06-15
卷号: 25, 期号:12, 页码:2469-2472
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Chemistry, Organic
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21333
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Inst Med Sci, Kunming 650011, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China
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