Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities
Yan, Yong-Ming1,2; Li, Li-Ji3; Qin, Xiao-Chu4,5; Lu, Qing1; Tu, Zheng-Chao4,5; Cheng, Yong-Xian1; Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; yxcheng@mail.kib.ac.cn
2015-06-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号25期号:12页码:2469-2472
摘要Blapsols A-D (1-4), four new compounds possessing a 2,3-dihydrobenzo[b][1,4]dioxin group, together with five known N-acetyldopamine dimers (5-9), were isolated from Blaps japanensis. Their structures including the absolute configuration of (+)-1 were determined by means of spectroscopic and X-ray crystallographic methods. Chiral HPLC was used to separate (-)- and (+)-enantiomers of compounds 1-4, which were isolated from this insect as racemic mixtures. All the compounds were found to have inhibitory effects towards COX-2 with IC50 values in the range of 1.3-17.8 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Blaps Japanensis Insects N-acetyldopamine Dimers Cox-1 Cox-2
资助信息National Natural Science Foundation of China [21172223]; Research Fund of 'South Drug' Research Collaborative Innovation Organization
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2015.04.085
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000355147300002
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21333
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Tu,ZC (reprint author),Chinese Acad Sci,Guangzhou Inst Biomed & Hlth,Key Lab Regenerat Biol,Guangzhou 510530,Guangdong,Peoples R China.; yxcheng@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Inst Med Sci, Kunming 650011, Peoples R China
4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China
5.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Inst Chem Biol, Guangzhou 510530, Guangdong, Peoples R China
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Yan, Yong-Ming,Li, Li-Ji,Qin, Xiao-Chu,et al. Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(12):2469-2472.
APA Yan, Yong-Ming.,Li, Li-Ji.,Qin, Xiao-Chu.,Lu, Qing.,Tu, Zheng-Chao.,...&yxcheng@mail.kib.ac.cn.(2015).Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(12),2469-2472.
MLA Yan, Yong-Ming,et al."Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.12(2015):2469-2472.
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