Targeting cancer with sesterterpenoids: the new potential antitumor drugs
Zhang, Caiguo1; Liu, Yan2; Liu,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Photochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; caiguo.zhang@ucdenver.edu; liuyan@mail.kib.ac.cn
2015-07-01
Source PublicationJOURNAL OF NATURAL MEDICINES
Volume69Issue:3Pages:255-266
AbstractCancer remains a major cause of death in the world to date. A variety of anticancer drugs have been used in clinical chemotherapy, acting on the particular oncogenic abnormalities that are responsible for malignant transformation and progression. Interestingly, some of these anticancer drugs are developed from natural sources such as plants, marine organisms, and microorganisms. Over the past decades, a family of naturally occuring molecules, namely sesterterpenoids, has been isolated from different organisms and they exhibit significant potential in the inhibition of tumor cells in vitro, while the molecular targets of these compounds and their functional mechanisms are still obscure. In this review, we summarize and discuss the functions of these sesterterpenoids in the inhibition of cancer cells. Moreover, we also highlight and discuss chemical structure-activity relationships of some compounds, demonstrating their pervasiveness and importance in cancer therapy.
KeywordTerpenoids Sesterterpenoids Cancer Therapy Structure-activity Relationship
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s11418-015-0911-y
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000355875800001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21329
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiu,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Photochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; caiguo.zhang@ucdenver.edu; liuyan@mail.kib.ac.cn
Affiliation1.Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Caiguo,Liu, Yan,Liu,Y ,et al. Targeting cancer with sesterterpenoids: the new potential antitumor drugs[J]. JOURNAL OF NATURAL MEDICINES,2015,69(3):255-266.
APA Zhang, Caiguo,Liu, Yan,Liu,Y ,caiguo.zhang@ucdenver.edu,&liuyan@mail.kib.ac.cn.(2015).Targeting cancer with sesterterpenoids: the new potential antitumor drugs.JOURNAL OF NATURAL MEDICINES,69(3),255-266.
MLA Zhang, Caiguo,et al."Targeting cancer with sesterterpenoids: the new potential antitumor drugs".JOURNAL OF NATURAL MEDICINES 69.3(2015):255-266.
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