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题名: Targeting cancer with sesterterpenoids: the new potential antitumor drugs
作者: Zhang, Caiguo1; Liu, Yan2
刊名: JOURNAL OF NATURAL MEDICINES
关键词: Terpenoids ; Sesterterpenoids ; Cancer therapy ; Structure-activity relationship
英文摘要: Cancer remains a major cause of death in the world to date. A variety of anticancer drugs have been used in clinical chemotherapy, acting on the particular oncogenic abnormalities that are responsible for malignant transformation and progression. Interestingly, some of these anticancer drugs are developed from natural sources such as plants, marine organisms, and microorganisms. Over the past decades, a family of naturally occuring molecules, namely sesterterpenoids, has been isolated from different organisms and they exhibit significant potential in the inhibition of tumor cells in vitro, while the molecular targets of these compounds and their functional mechanisms are still obscure. In this review, we summarize and discuss the functions of these sesterterpenoids in the inhibition of cancer cells. Moreover, we also highlight and discuss chemical structure-activity relationships of some compounds, demonstrating their pervasiveness and importance in cancer therapy.
出版日期: 2015-07-01
卷号: 69, 期号:3, 页码:255-266
DOI标识: 10.1007/s11418-015-0911-y
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21329
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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