Targeting cancer with sesterterpenoids: the new potential antitumor drugs
Zhang, Caiguo1; Liu, Yan2; Liu,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Photochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; caiguo.zhang@ucdenver.edu; liuyan@mail.kib.ac.cn
2015-07-01
发表期刊JOURNAL OF NATURAL MEDICINES
卷号69期号:3页码:255-266
摘要Cancer remains a major cause of death in the world to date. A variety of anticancer drugs have been used in clinical chemotherapy, acting on the particular oncogenic abnormalities that are responsible for malignant transformation and progression. Interestingly, some of these anticancer drugs are developed from natural sources such as plants, marine organisms, and microorganisms. Over the past decades, a family of naturally occuring molecules, namely sesterterpenoids, has been isolated from different organisms and they exhibit significant potential in the inhibition of tumor cells in vitro, while the molecular targets of these compounds and their functional mechanisms are still obscure. In this review, we summarize and discuss the functions of these sesterterpenoids in the inhibition of cancer cells. Moreover, we also highlight and discuss chemical structure-activity relationships of some compounds, demonstrating their pervasiveness and importance in cancer therapy.
关键词Terpenoids Sesterterpenoids Cancer Therapy Structure-activity Relationship
资助信息National Natural Science Foundation of China [31470395]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1007/s11418-015-0911-y
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000355875800001
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21329
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Photochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; caiguo.zhang@ucdenver.edu; liuyan@mail.kib.ac.cn
作者单位1.Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Zhang, Caiguo,Liu, Yan,Liu,Y ,et al. Targeting cancer with sesterterpenoids: the new potential antitumor drugs[J]. JOURNAL OF NATURAL MEDICINES,2015,69(3):255-266.
APA Zhang, Caiguo,Liu, Yan,Liu,Y ,caiguo.zhang@ucdenver.edu,&liuyan@mail.kib.ac.cn.(2015).Targeting cancer with sesterterpenoids: the new potential antitumor drugs.JOURNAL OF NATURAL MEDICINES,69(3),255-266.
MLA Zhang, Caiguo,et al."Targeting cancer with sesterterpenoids: the new potential antitumor drugs".JOURNAL OF NATURAL MEDICINES 69.3(2015):255-266.
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