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Xanthine oxidase inhibitors isolated from Piper nudibaccatum
Liu, Hong-Xin1,2,3,4; He, Meng-Ting5; Tan, Hai-Bo3; Gu, Wei1,2; Yang, Shi-Xian1,2; Wang, Yue-Hu1,2; Li, Ling5; Long, Chun-Lin1,2,6; Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn
2015-06-01
Source PublicationPHYTOCHEMISTRY LETTERS
Volume12Issue:1Pages:133-137
Abstract

Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1-5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 mu M) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 mu M and 70.67 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

KeywordPiper Nudibaccatum Hydroxychavicol Nudibaccatumin a Nudibaccatumin b Xanthine Oxidase
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytol.2015.03.005
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000356336400025
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/21321
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorLong,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China
6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Liu, Hong-Xin,He, Meng-Ting,Tan, Hai-Bo,et al. Xanthine oxidase inhibitors isolated from Piper nudibaccatum[J]. PHYTOCHEMISTRY LETTERS,2015,12(1):133-137.
APA Liu, Hong-Xin.,He, Meng-Ting.,Tan, Hai-Bo.,Gu, Wei.,Yang, Shi-Xian.,...&long@mail.kib.ac.cn.(2015).Xanthine oxidase inhibitors isolated from Piper nudibaccatum.PHYTOCHEMISTRY LETTERS,12(1),133-137.
MLA Liu, Hong-Xin,et al."Xanthine oxidase inhibitors isolated from Piper nudibaccatum".PHYTOCHEMISTRY LETTERS 12.1(2015):133-137.
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