Xanthine oxidase inhibitors isolated from Piper nudibaccatum
Liu, Hong-Xin1,2,3,4; He, Meng-Ting5; Tan, Hai-Bo3; Gu, Wei1,2; Yang, Shi-Xian1,2; Wang, Yue-Hu1,2; Li, Ling5; Long, Chun-Lin1,2,6; Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn
2015-06-01
发表期刊PHYTOCHEMISTRY LETTERS
卷号12页码:133-137
摘要Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1-5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 mu M) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 mu M and 70.67 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Piper Nudibaccatum Hydroxychavicol Nudibaccatumin a Nudibaccatumin b Xanthine Oxidase
资助信息National Natural Science Foundation of China [31161140345, 31070288, 81360505]; Natural Science Foundation of Yunnan Province, China [2011FZ205, 2013FA017]; Ministry of Science & Technology of China [2012FY110300]; Ministry of Education of China [B08044, MUC985]; JSPS Asian Core program [JSPS/AP/109080]
学科领域Biochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytol.2015.03.005
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000356336400025
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/21321
专题资源植物与生物技术所级重点实验室
通讯作者Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China
6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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GB/T 7714
Liu, Hong-Xin,He, Meng-Ting,Tan, Hai-Bo,et al. Xanthine oxidase inhibitors isolated from Piper nudibaccatum[J]. PHYTOCHEMISTRY LETTERS,2015,12:133-137.
APA Liu, Hong-Xin.,He, Meng-Ting.,Tan, Hai-Bo.,Gu, Wei.,Yang, Shi-Xian.,...&long@mail.kib.ac.cn.(2015).Xanthine oxidase inhibitors isolated from Piper nudibaccatum.PHYTOCHEMISTRY LETTERS,12,133-137.
MLA Liu, Hong-Xin,et al."Xanthine oxidase inhibitors isolated from Piper nudibaccatum".PHYTOCHEMISTRY LETTERS 12(2015):133-137.
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