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题名: Xanthine oxidase inhibitors isolated from Piper nudibaccatum
作者: Liu, Hong-Xin1, 2, 3, 4; He, Meng-Ting5; Tan, Hai-Bo3; Gu, Wei1, 2; Yang, Shi-Xian1, 2; Wang, Yue-Hu1, 2; Li, Ling5; Long, Chun-Lin1, 2, 6
刊名: PHYTOCHEMISTRY LETTERS
出版日期: 2015-06-01
卷号: 12, 页码:133-137
关键词: Piper nudibaccatum ; Hydroxychavicol ; Nudibaccatumin A ; Nudibaccatumin B ; Xanthine oxidase
学科分类: Biochemistry & Molecular Biology; Plant Sciences
DOI: 10.1016/j.phytol.2015.03.005
通讯作者: Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China. ; kmli62@163.com ; long@mail.kib.ac.cn
文章类型: Article
英文摘要: Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1-5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 mu M) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 mu M and 70.67 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: LONGUM L ; FLAVONOIDS ; AMIDE ; CONSTITUENTS ; DERIVATIVES ; MECHANISM ; FRUITS ; ACID ; GOUT
收录类别: SCI
项目资助者: National Natural Science Foundation of China [31161140345, 31070288, 81360505] ; Natural Science Foundation of Yunnan Province, China [2011FZ205, 2013FA017] ; Ministry of Science & Technology of China [2012FY110300] ; Ministry of Education of China [B08044, MUC985] ; JSPS Asian Core program [JSPS/AP/109080]
语种: 英语
WOS记录号: WOS:000356336400025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/21321
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China
6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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