Xanthine oxidase inhibitors isolated from Piper nudibaccatum | |
Liu, Hong-Xin1,2,3,4; He, Meng-Ting5; Tan, Hai-Bo3; Gu, Wei1,2; Yang, Shi-Xian1,2; Wang, Yue-Hu1,2; Li, Ling5; Long, Chun-Lin1,2,6; Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn | |
2015-06-01 | |
发表期刊 | PHYTOCHEMISTRY LETTERS |
卷号 | 12期号:1页码:133-137 |
摘要 | Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1-5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 mu M) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 mu M and 70.67 mu M, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
关键词 | Piper Nudibaccatum Hydroxychavicol Nudibaccatumin a Nudibaccatumin b Xanthine Oxidase |
学科领域 | Biochemistry & Molecular Biology ; Plant Sciences |
DOI | 10.1016/j.phytol.2015.03.005 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000356336400025 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/21321 |
专题 | 资源植物与生物技术所级重点实验室 |
通讯作者 | Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,Beijing 100081,Peoples R China.; kmli62@163.com; long@mail.kib.ac.cn |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China 6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China |
推荐引用方式 GB/T 7714 | Liu, Hong-Xin,He, Meng-Ting,Tan, Hai-Bo,et al. Xanthine oxidase inhibitors isolated from Piper nudibaccatum[J]. PHYTOCHEMISTRY LETTERS,2015,12(1):133-137. |
APA | Liu, Hong-Xin.,He, Meng-Ting.,Tan, Hai-Bo.,Gu, Wei.,Yang, Shi-Xian.,...&long@mail.kib.ac.cn.(2015).Xanthine oxidase inhibitors isolated from Piper nudibaccatum.PHYTOCHEMISTRY LETTERS,12(1),133-137. |
MLA | Liu, Hong-Xin,et al."Xanthine oxidase inhibitors isolated from Piper nudibaccatum".PHYTOCHEMISTRY LETTERS 12.1(2015):133-137. |
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